Copper-Mediated Late-stage Radiofluorination: Five Years of Impact on Pre-clinical and Clinical PET Imaging.
Copper-Mediated Late-stage Radiofluorination: Five Years of Impact on Pre-clinical and Clinical PET Imaging.
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DOI：
10.1007/s40336-020-00368-y
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发表时间：
2020-06
影响因子：
2.1
通讯作者：
Scott PJH
中科院分区：
文献类型：
--
作者：
Wright JS;Kaur T;Preshlock S;Tanzey SS;Winton WP;Sharninghausen LS;Wiesner N;Brooks AF;Sanford MS;Scott PJH
铜介导的放射性氟化 (CMRF) 正在成为形成芳香族 C-18F 键的首选方法。这篇小型综述探讨了含有用 CMRF 合成的芳香族 C-18F 键的新型和已建立的显像剂的概念验证、临床前和人体成像研究。虽然讨论了使氟 18 显像剂合成成为可能或改进的关键进展，但没有提供对 CMRF 方法的详尽讨论。自 2014 年 4 月起，我们对 Web of Science 和 PubMed 图书馆数据库进行了全面的文献检索，以查找利用 CMRF 合成氟 18 放射性药物的报告，这些报告代表了本小型评论中讨论的主要研究主体。选择的会议记录、先前描述显像剂合成替代方法的报告以及先前的 19 氟方法也已纳入讨论。 CMRF 显着扩大了氟 18 放射性标记的化学空间，其生产方法可以满足核医学使用的监管要求。此外，它还实现了放射性药物的新颖且改进的合成，并促进了后续 PET 成像研究。 CMRF 的快速采用无疑将继续简化显像剂的生产并激发新的放射性氟化方法的开发。
Copper-mediated radiofluorination (CMRF) is emerging as the method of choice for the formation of aromatic C-18F bonds. This minireview examines proof-of-concept, pre-clinical, and in-human imaging studies of new and established imaging agents containing aromatic C-18F bonds synthesized with CMRF. An exhaustive discussion of CMRF methods is not provided, although key developments that have enabled or improved upon the syntheses of fluorine-18 imaging agents are discussed. A comprehensive literature search from April 2014 onwards of the Web of Science and PubMed library databases was performed to find reports that utilize CMRF for the synthesis of fluorine-18 radiopharmaceuticals, and these represent the primary body of research discussed in this minireview. Select conference proceedings, previous reports describing alternative methods for the synthesis of imaging agents, and preceding fluorine-19 methodologies have also been included for discussion. CMRF has significantly expanded the chemical space that is accessible to fluorine-18 radiolabeling with production methods that can meet the regulatory requirements for use in Nuclear Medicine. Furthermore, it has enabled novel and improved syntheses of radiopharmaceuticals and facilitated subsequent PET imaging studies. The rapid adoption of CMRF will undoubtedly continue to simplify the production of imaging agents and inspire the development of new radiofluorination methodologies.
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DOI：
10.1002/jlcr.2580250211
发表时间：
1988-02-01
影响因子：
1.8
作者：
BLOCK, D;COENEN, HH;STOCKLIN, G
通讯作者：
STOCKLIN, G
影响因子：
4.6
作者：
Clemente, Goncalo S.;Zarganes-Tzitzikas, Tryfon;Elsinga, Philip H.
通讯作者：
Elsinga, Philip H.
影响因子：
7.3
作者：
Bernard-Gauthier, Vadim;Mossine, Andrew V.;Schirrmacher, Ralf
通讯作者：
Schirrmacher, Ralf
影响因子：
7.3
作者：
Bratteby, Klas;Torkelsson, Edvard;Erlandsson, Maria
通讯作者：
Erlandsson, Maria
影响因子：
3.1
作者：
Constantinescu, Cristian C.;Tresse, Cedric;Barret, Olivier
通讯作者：
Barret, Olivier