Visible-Light-Induced Oxidation of Diazenyl-Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams
Visible-Light-Induced Oxidation of Diazenyl-Protected Tetrahydroisoquinolines and Isoindolines for the Synthesis of Functionalized Lactams
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二氮烯基保护的四氢异喹啉和异吲哚啉的可见光诱导氧化用于合成功能化内酰胺
DOI：
10.1002/adsc.202101506
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Yonghong Zhang
中科院分区：
文献类型：
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作者：
Tao Zhang;Yanhong Wang;Bin Wang;Weiwei Jin;Yu Xia;Chenjiang Liu;Yonghong Zhang
研究了一种可见光诱导氧化保护二氮基的四氢异喹啉和异吲哚合成结构多样的内酰胺的方法。以伊红Y - na2为有机光催化剂，分子氧为氧化剂，在温和和无过渡金属的条件下得到了功能化的n -芳基二氮基内酰胺。用克级合成和脱保护的结果证明了该方法的实用性。
A visible‐light‐induced oxidation of diazenyl‐protected tetrahydroisoquinolines and isoindolines for the synthesis of structurally diverse lactams is developed. The reaction was carried out with Eosin Y‐Na2as an organic photocatalyst and molecular oxygen as an oxidant, and the desired functionalizedN‐aryldiazenyl‐lactams were obtained under mild and transition metal‐free conditions. The utility of this method is showcased by the gram‐scale synthesis and deprotection of theN‐aryldiazenyl‐lactam product.