Facile synthesis of aziridines from imines and diazoesters or aldehydes, amines, and diazoesters using a catalytic amount of lanthanide triflate
Facile synthesis of aziridines from imines and diazoesters or aldehydes, amines, and diazoesters using a catalytic amount of lanthanide triflate
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DOI：
10.1246/cl.1998.685
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发表时间：
1998-07-01
影响因子：
1.6
通讯作者：
Kobayashi, S
中科院分区：
文献类型：
--
作者：
Nagayama, S;Kobayashi, S
在催化量的三氟甲磺酸镧（Ln（OTf）（3））存在下，亚胺与重氮酯乙酯在室温下于己烷中反应，以高产率和高的非对映选择性得到相应的氮杂环丙烷.基于这些反应，已经开发了各种类型的醛、胺和重氮酯乙酯的三组分反应，以提供氮丙啶衍生物的通用有效路线。
In the presence of a catalytic amount of lanthanide triflate (Ln(OTf)(3)), imines reacted with ethyl diazoester in hexane at room temperature to afford the corresponding aziridines in high yields with high diastereoselectivities. Based on these reactions, three-component reactions of various types of aldehydes, an amine, and ethyl diazoester have been developed to provide a general efficient route to aziridine derivatives.