Study on MEMS Colon Cancer Cell Capturing Chip
Study on MEMS Colon Cancer Cell Capturing Chip
复制标题
MEMS结肠癌细胞捕获芯片的研究
DOI：
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发表时间：
2011
期刊：
影响因子：
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通讯作者：
Xia J.
中科院分区：
文献类型：
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作者：
Hu R.-J.;Chen D.;Chen X.;Chen J.-D.;Wu C.;Du H.-X.;Yang Z.-L.;Wang Z.-G.;Xia J.
癌症是威胁人类健康的主要疾病之一。如何快速、简便地分离出癌细胞，是摆在临床医务人员和科研人员面前的一个难题。结合磁珠技术和MEMS技术，设计了等边三角形排列的Ni微磁柱，利用CD326免疫磁珠在磁场中捕获结肠癌细胞。本文完成了MEMS细胞捕获芯片的设计、微加工和封装。他们捕获了与磁珠结合的结肠癌细胞。在0.1ml/h速度下，捕获效率为92%，表明该芯片具有捕获癌细胞的能力。
Cancer is one of the major diseases threatening human health.It is a thorny problem to isolate cancer cells fast and easily for clinical medical officers and scientific researchers.Combining magnetic bead technology and MEMS technology,Ni micro-magnetic cylinder arranged in an equilateral triangle is designed to capture colon cancer cells using CD326 immune magnetic beads in magnetic field.In this paper,MEMS cell capturing chip was designed,micro-fabricated,and packaged.Colon cancer cells combined with magnetic beads were captured.The capture efficiency is 92% under 0.1ml/h velocity,indicating that the chip has the ability to capture cancer cells.