Neurometabolite Concentrations in Gray and White Matter in Mild Traumatic Brain Injury: An 1H-Magnetic Resonance Spectroscopy Study
Neurometabolite Concentrations in Gray and White Matter in Mild Traumatic Brain Injury: An 1H-Magnetic Resonance Spectroscopy Study
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DOI：
10.1089/neu.2009.0896
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发表时间：
2009-10-01
影响因子：
4.2
通讯作者：
Mayer, Andrew R.
中科院分区：
文献类型：
--
作者：
Gasparovic, Charles;Yeo, Ronald;Mayer, Andrew R.
应用单体素质子磁共振成像(H-1-MRS)和质子磁共振波谱成像(H-1-MRSI)对10例半急性轻型颅脑损伤(MTBI)患者和9例健康对照的脑代谢产物水平进行比较。H-1-MRS体素定位在压部，这是已知的脑损伤轴索损伤的易感区域，单个H-1-MRSI切片定位在侧脑室上方。为了提高对谷氨酸(Glu)和谷氨酸-谷氨酰胺(GLX)组合信号的灵敏度，采用了脉间回波时间来强调主要的Glu信号，并使用了一种分析方法，通过使用水作为浓度标准来减少部分体积误差。我们的初步发现表明，与健康对照组相比，mTBI受试者的灰质GLX水平显著降低，而白质肌酸-磷酸肌酸(Cr)水平显著升高。此外，在联合组中，肌酸水平可以预测执行功能和情绪困扰。这些结果表明，大脑能量代谢的关键组成部分肌酸和大脑主要神经递质谷氨酸的扰动可能发生在mTBI之后。此外，灰质和白质结果的不同模式表明，对mTBI的代谢反应具有组织特异性。
Single-voxel proton magnetic resonance imaging (H-1-MRS) and proton MR spectroscopic imaging (H-1-MRSI) were used to compare brain metabolite levels in semi-acute mild traumatic brain injury (mTBI) patients (n = 10) and matched healthy controls (n = 9). The H-1-MRS voxel was positioned in the splenium, a region known to be susceptible to axonal injury in TBI, and a single H-1-MRSI slice was positioned above the lateral ventricles. To increase sensitivity to the glutamate (Glu) and the combined glutamate-glutamine (Glx) signal, an inter-pulse echo time shown to emphasize the major Glu signals was used along with an analysis method that reduces partial volume errors by using water as a concentration standard. Our preliminary findings indicate significantly lower levels of gray matter Glx and higher levels of white matter creatine-phosphocreatine (Cr) in mTBI subjects relative to healthy controls. Furthermore, Cr levels were predictive of executive function and emotional distress in the combined groups. These results suggest that perturbations in Cr, a critical component of the brain's energy metabolism, and Glu, the brain's major neurotransmitter, may occur following mTBI. Moreover, the different pattern of results for gray and white matter suggests tissue-specific metabolic responses to mTBI.