A Simple Model of Cortical Dynamics Explains Variability and State Dependence of Sensory Responses in Urethane-Anesthetized Auditory Cortex
A Simple Model of Cortical Dynamics Explains Variability and State Dependence of Sensory Responses in Urethane-Anesthetized Auditory Cortex
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DOI：
10.1523/jneurosci.2053-09.2009
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发表时间：
2009-08-26
影响因子：
5.3
通讯作者：
Harris, Kenneth D.
中科院分区：
文献类型：
--
作者：
Curto, Carina;Sakata, Shuzo;Harris, Kenneth D.
新皮质细胞对感觉刺激的反应是可变的和状态依赖的。有人假设，固有的皮质动力学在试验之间的可变性中起着重要作用；然而，这种依赖性的确切性质却鲜为人知。我们在这里表明，在乌拉坦麻醉的大鼠的听觉皮质中，群体对短声刺激的反应可以通过一个简单的动力系统模型在逐个试验的基础上进行定量预测，该模型根据刺激呈现之前的自发活动进行估计。大脑皮层状态的变化与模型动力学的变化一致，反映了同步状态下的非线性自激系统和去同步状态下的近似线性系统。我们认为，试验之间的复杂和状态相关的可变性模式可以用一个简单的原理来解释：感官反应是由支配正在进行的自发活动的相同的内在动力塑造的。
The responses of neocortical cells to sensory stimuli are variable and state dependent. It has been hypothesized that intrinsic cortical dynamics play an important role in trial-to-trial variability; the precise nature of this dependence, however, is poorly understood. We show here that in auditory cortex of urethane-anesthetized rats, population responses to click stimuli can be quantitatively predicted on a trial-by-trial basis by a simple dynamical system model estimated from spontaneous activity immediately preceding stimulus presentation. Changes in cortical state correspond consistently to changes in model dynamics, reflecting a nonlinear, self-exciting system in synchronized states and an approximately linear system in desynchronized states. We propose that the complex and state-dependent pattern of trial-to-trial variability can be explained by a simple principle: sensory responses are shaped by the same intrinsic dynamics that govern ongoing spontaneous activity.