Fc-receptor heterogeneity of human suppressor T cells.
Fc-receptor heterogeneity of human suppressor T cells.
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人类抑制性 T 细胞的 Fc 受体异质性。
DOI：
10.4049/jimmunol.121.1.1
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发表时间：
1978
影响因子：
4.4
通讯作者：
Alexander R. Lawton
中科院分区：
文献类型：
--
作者：
Anthony R. Hayward;Lorna Layward;Peter M. Lydyard;L. Moretta;M. Dagg;Alexander R. Lawton
伴刀豆球蛋白A（Con A）刺激人T细胞的IgM结合亚群（TM），以抑制商陆丝裂原诱导的B淋巴细胞向浆细胞的分化。未被Con A激活的对照TM细胞没有抑制作用。抑制程度与添加到培养物中的Con A - TM细胞数量有关，并且在Con A培养24小时之前或之后对T淋巴细胞进行照射可消除这种抑制作用。抑制作用不需要TG细胞的存在，TG细胞的抑制潜能先前已被确定。这些发现表明，抑制活性不限于TG亚群，TM细胞也可能表达抑制活性。
Concanavalin A (Con A) stimulated the IgM-binding subpopulation of human T cells (TM) to suppress the pokeweed mitogen-induced differentiation of B lymphocytes to plasma cells. Control TM cells that had not been Con A activated did not suppress. The degree of suppression was related to the number of Con A-TM cells added to the cultures and it was abolished by irradiation of the T lymphocytes either before or after the 24-hr culture period with Con A. Suppression did not require the presence of TG cells, whose suppressor potential has been previously established. These findings indicate that suppressor activity is not confined to the TG subpopulation but may be expressed by TM cells also.