Ultrashort echo time spectroscopic imaging (UTESI): an efficient method for quantifying bound and free water
Ultrashort echo time spectroscopic imaging (UTESI): an efficient method for quantifying bound and free water
复制标题
DOI：
10.1002/nbm.1728
复制
发表时间：
2012-01-01
影响因子：
2.9
通讯作者：
Du, Jiang
中科院分区：
文献类型：
--
作者：
Diaz, Eric;Chung, Christine B.;Du, Jiang
生物组织通常含有不同的水隔，具有不同的横向弛豫时间。本研究采用二维、多层、超短回波时间光谱成像(UTESI)结合双组分分析技术，对肌肉骨骼组织中的结合水和自由水成分进行了检测。利用数值模拟进行了可行性研究。对牛皮质骨、人身体半月板和志愿者跟腱进行成像。模拟研究表明，UTESI与双成分分析相结合，可以可靠地量化T2*以及短T2*和长T2*分量的分数。体外和体内研究均不到14分钟。结合水成分的T2*短，牛骨为0.3ms，半月板为1.8ms，跟腱为0.6ms。游离水成分的T2*值大一个数量级，牛骨为2ms，半月板为14ms，跟腱为8ms。测定了牛骨、半月板和跟腱的结合水含量，分别为76%、50%和75%。按体积计算，牛骨、半月板和跟腱的游离水含量分别为24%、50%和25%。这些结果表明，UTESI结合双组分分析，可以在临床实际情况下定量肌肉骨骼组织中的结合水和自由水成分。版权所有(C)2011 John Wiley&Sons，Ltd.
Biological tissues usually contain distinct water compartments with different transverse relaxation times. In this study, two-dimensional, multi-slice, ultrashort echo time spectroscopic imaging (UTESI) was used with bi-component analysis to detect bound and free water components in musculoskeletal tissues. Feasibility studies were performed using numerical simulation. Imaging was performed on bovine cortical bone, human cadaveric menisci and the Achilles' tendons of volunteers. The simulation study demonstrated that UTESI, together with bi-component analysis, could reliably quantify both T2* and fractions of the short and long T2* components. The in vitro and in vivo studies each took less than 14min. The bound water components showed a short T2* of similar to 0.3ms for bovine bone, similar to 1.8ms for meniscus and similar to 0.6ms for the Achilles' tendon. The free water components showed about an order of magnitude longer T2* values, with similar to 2ms for bovine bone, similar to 14ms for meniscus and similar to 8ms for the Achilles' tendon. Bound water fractions of up to similar to 76% for bovine bone, 50% for meniscus and similar to 75% for the Achilles' tendon were measured. The corresponding free water components were up to similar to 24% for bovine bone, 50% for meniscus and similar to 25% for the Achilles' tendon by volume. These results demonstrate that UTESI, combined with bi-component analysis, can quantify the bound and free water components in musculoskeletal tissues in clinically realistic times. Copyright (c) 2011 John Wiley & Sons, Ltd.