Startle amplitude and fear in an acoustic startle paradigm: Lesions to the brachium of the inferior colliculus or the lateral tegmental tract
Startle amplitude and fear in an acoustic startle paradigm: Lesions to the brachium of the inferior colliculus or the lateral tegmental tract
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DOI：
10.1037/0735-7044.115.2.477
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发表时间：
2001-04-01
影响因子：
1.9
通讯作者：
Brucato, FH
中科院分区：
文献类型：
--
作者：
Leaton, RN;Brucato, FH
在2个实验中，惊吓幅度和惊吓刺激诱导的冻结（恐惧指数）在大鼠的声惊吓反应（ASR）范例中进行了测量。外侧被盖束（LTG）病变。与假手术对照组相比，下丘（BIC）臂内侧的通路显著减少了冻结，并使ASR振幅持续增加5倍。BIC病变增加ASR幅度（2倍）和冻结。BIC或LTG病变都不影响惊吓幅度时，惊吓引起的短暂的足电击刺激。损伤效应的特点进行了测试与操纵的刺激间隔，刺激强度，和前脉冲抑制。这些数据表明：（a）BIC内侧的上行通路携带声音刺激的恐惧诱导维度，（B）下行通路提供对ASR电路的感觉输入的紧张性抑制。
In 2 experiments, startle amplitude and startle stimulus-induced freezing (an index of fear) were measured in an acoustic startle response (ASR) paradigm in rats. Lesions to lateral tegmental tract (LTG). a pathway medial to brachium of the inferior colliculus (BIC), significantly decreased freezing and produced a persistent 5-fold increase in ASR amplitude compared with sham-operated controls. Lesions to BIC increased both ASR amplitude (2-fold) and freezing. Neither BIC nor LTG lesions affected startle amplitude when startle was elicited by a brief footshock stimulus. Characteristics of the lesion effects were tested with manipulations of interstimulus interval, stimulus intensity, and prepulse inhibition. The data suggest (a) an ascending pathway medial to BIC that carries the fear-inducing dimensions of an acoustic stimulus and (b) a descending pathway that provides tonic inhibition of the sensory input to the ASR circuitry.