Rats with different profiles of impulsive choice behavior exhibit differences in responses to caffeine and d-amphetamine and in medial prefrontal cortex 5-HT utilization
Rats with different profiles of impulsive choice behavior exhibit differences in responses to caffeine and d-amphetamine and in medial prefrontal cortex 5-HT utilization
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DOI：
10.1016/j.bbr.2007.09.020
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发表时间：
2008-03-05
影响因子：
2.7
通讯作者：
Majchrzak, Monique
中科院分区：
文献类型：
--
作者：
Barbelivien, Alexandra;Billy, Erwan;Majchrzak, Monique
本研究调查了在延迟强化任务中，以冲动性（BLI）为基础的大鼠亚群是否表现出调节冲动选择行为的神经递质系统功能的差异。为此，研究了不同剂量的咖啡因和d-苯丙胺在三个亚群的大鼠中的作用，这些大鼠在其冲动选择行为中表现出明显的差异，并评估了它们的死后多巴胺能和多巴胺能功能。咖啡因和d-安非他明减少冲动的选择行为，只有在中等BLI亚群。多巴胺的利用率是相似的三个亚群，但血清素的利用率较低的中，非常高的BLI亚群相比，低BLI的前额叶皮层。这些结果表明，咖啡因和d-苯丙胺的抗冲动作用依赖于大鼠的BLI，并且前额叶皮层中的低多巴胺能功能可能是由冲动选择行为评估的冲动性的特征标记。(C)2007 Elsevier B. V.保留所有权利。
This study investigated if sub-populations of rats characterized by their basal level of impulsivity (BLI) in a delayed-reinforcement task, displayed differences in the functioning of neurotransmitter systems modulating impulsive choice behavior. For this, the effects of various doses of caffeine and d-amphetamine were investigated in three sub-populations of rats displaying pronounced differences in their impulsive choice behavior and their post-mortem serotonergic and dopaminergic functions were assessed. Caffeine and d-amphetamine reduce impulsive choice behavior only in the Medium BLI sub-population. Dopamine utilization was similar in the three sub-populations, but serotonin utilization was lower in the prefrontal cortex of the Medium and Very high BLI sub-populations as compared to the low BLI one. These results suggest that anti-impulsive effects of caffeine and d-amphetamine are dependent on the BLI of rats and that a low serotonergic function in the prefrontal cortex may be a trait marker of impulsivity evaluated by impulsive choice behavior. (C) 2007 Elsevier B.V. All rights reserved.