Timing of Modulation of Corticospinal Excitability by Heartbeat Differs with Interoceptive Accuracy
Timing of Modulation of Corticospinal Excitability by Heartbeat Differs with Interoceptive Accuracy
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心跳调节皮质脊髓兴奋性的时间随内感受准确性的不同而不同
DOI：
10.1016/j.neuroscience.2020.03.014
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发表时间：
2020
期刊：
影响因子：
3.3
通讯作者：
Onishi Hideaki
中科院分区：
文献类型：
--
作者：
Otsuru Naofumi;Miyaguchi Shota;Kojima Sho;Yamashiro Koya;Sato Daisuke;Yokota Hirotake;Saito Kei;Inukai Yasuto;Onishi Hideaki
内感受输入是来自内部身体的上升信息。研究表明，皮质活动是由R波后约200-600 ms心跳的内感受性输入引起的，并且感觉处理是由时间窗口内的心跳调制的。然而，内感受性输入和它们的时机对皮质脊髓兴奋性的影响尚未完全阐明。此外，在以往的研究中，个体差异的内感受准确性，客观准确性，在检测内部身体感觉评估的心跳感知任务，可以被认为是一个重要的因素，影响皮层活动的心跳。因此，我们调查的调制皮质脊髓兴奋性的心跳和它的时间通过记录运动诱发电位引起的经颅磁刺激的初级运动皮层在不同的时间从R波。我们还研究了这种调制和个体内感受准确性之间的关系。我们发现R波后200 ms皮质脊髓兴奋性的调制与内感受性准确性之间存在显著正相关。相反，我们发现R波后400 ms皮质脊髓兴奋性的调制与内感受性准确性之间存在显著的负相关。这些结果表明，皮质脊髓兴奋性调制后200-400 ms的R波（收缩期）和兴奋或抑制状态的皮质脊髓通路的时间与内感受性的准确性不同。虽然神经机制仍不清楚，这些发现可能有助于确定影响皮质脊髓兴奋性的新因素。
Interoceptive inputs are ascending information from the internal body. Cortical activities have been shown to be elicited by interoceptive inputs from the heartbeat at approximately 200–600 ms after the R wave, and sensory processing is modulated by the heartbeat within the time window. However, the influence of interoceptive inputs and their timing on corticospinal excitability has not yet been fully elucidated. Moreover, in previous studies, individual differences in interoceptive accuracy—objective accuracy in detecting internal bodily sensations assessed by heartbeat perception tasks—can be considered as an important factor influencing cortical activities by the heartbeat. We therefore investigated the modulation of corticospinal excitability by the heartbeat and its timing by recording motor-evoked potentials elicited by transcranial magnetic stimulation of the primary motor cortex at various timings from the R wave. We also investigated the relationship between this modulation and individual interoceptive accuracy. We found a significant positive correlation between the modulation of corticospinal excitability at 200 ms after the R wave and interoceptive accuracy. Conversely, we found a significant negative correlation between the modulation of corticospinal excitability at 400 ms after the R wave and interoceptive accuracy. These results indicated that the corticospinal excitability was modulated at 200–400 ms after the R wave (systolic phase) and that the timing of excitatory or inhibitory states in the corticospinal pathway differed with interoceptive accuracy. Although the neural mechanism remains unclear, these findings may aid in determining new factors influencing corticospinal excitability.