Complete nucleotide sequence of the rhesus lymphocryptovirus: Genetic validation for an Epstein-Barr virus animal model
Complete nucleotide sequence of the rhesus lymphocryptovirus: Genetic validation for an Epstein-Barr virus animal model
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DOI：
10.1128/jvi.76.1.421-426.2002
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发表时间：
2002-01-01
影响因子：
5.4
通讯作者：
Wang, F
中科院分区：
文献类型：
--
作者：
Rivailler, P;Jiang, H;Wang, F
我们对恒河猴淋巴隐病毒（LCV）基因组进行了测序，以确定其与EB病毒（EBV）的遗传相似性。恒河猴LCV编码与EBV相同的所有基因，具有80个开放阅读框，包括细胞白细胞介素-10、bcl-2和集落刺激因子1受体同源物以及一组等效的病毒糖蛋白。恒河猴LCV基因组的高度保守性为研究EBV的发病机制提供了一个独特的动物模型。
We sequenced the rhesus lymphocryptovirus (LCV) genome in order to determine its genetic similarity to Epstein-Barr virus (EBV). The rhesus LCV encodes a repertoire identical to that of EBV, with 80 open reading frames, including cellular interleukin-10, bcl-2, and colony-stimulating factor 1 receptor homologues and an equivalent set of viral glycoproteins. The highly conserved rhesus LCV gene repertoire provides a unique animal model for the study of EBV pathogenesis.