Reduced interferon γ production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age
Reduced interferon γ production and soluble CD14 levels in early life predict recurrent wheezing by 1 year of age
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DOI：
10.1164/rccm.200304-499oc
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发表时间：
2004-01-01
影响因子：
24.7
通讯作者：
Wright, AL
中科院分区：
文献类型：
--
作者：
Guerra, S;Lohman, IC;Wright, AL
目前尚不清楚，在任何下呼吸道疾病之前，生命早期IFNgamma的产生减少是否是婴儿反复喘息的危险因素。我们对238名婴儿进行了前瞻性随访，从出生到1岁。在出生和3月龄时，测量多克隆刺激外周血单个核细胞产生IFNgamma和血浆中可溶性CD14 （sCD14）水平。与其他3个IFNgamma和sCD14联合四分位数的儿童相比，3个月时IFNgamma产生最低四分位数的儿童在出生后第一年发生复发性喘息的几率（通过问卷评估）高达4.5倍（p = 0.0005），出生时sCD14水平最低四分位数的儿童（p = 0.004）分别高出3.2倍（p = 0.004）。结果在多变量分析中得到证实。3月龄时IFNgamma的产生与出生时sCD14水平相关（r = 0.188, p = 0.031）。我们的纵向队列研究结果表明，3个月时IFNgamma生成受损和出生时血浆cd14水平降低显著增加了出生后第一年发生复发性喘息的风险。
It is unknown whether reduced production of IFNgamma in early life, before any lower respiratory tract illness, is a risk factor for recurrent wheezing in infancy. We followed 238 infants prospectively from birth to I year of age. At birth and at 3 months of age, IFNgamma production from polyclonally stimulated peripheral blood mononuclear cells and soluble CD14 (sCD14) levels in plasma were measured. The odds of developing recurrent wheezing (assessed by questionnaire) in the first year of life were up to 4.5 times higher for children in the lowest quartile of IFNgamma production at 3 months (p = 0.0005) and 3.2 times higher for children in the lowest quartile of sCD14 levels at birth (p = 0.004) as compared with children in the other 3 combined quartiles of IFNgamma and sCD14, respectively. Findings were confirmed in the multivariate analysis. IFNgamma production at 3 months and sCD14 levels at birth were correlated (r = 0.188, p = 0.031). Our findings from a longitudinal cohort suggest that impaired IFNgamma production at 3 months and reduced plasmasCD14 levels at birth significantly increase the risk of developing recurrent wheezing in the first year of life.