A simple route to develop transparent doxorubicin-loaded nanodiamonds/cellulose nanocomposite membranes as potential wound dressings.
A simple route to develop transparent doxorubicin-loaded nanodiamonds/cellulose nanocomposite membranes as potential wound dressings.
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DOI：
10.1016/j.carbpol.2016.01.076
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发表时间：
2016-06
影响因子：
11.2
通讯作者：
Xiaogang Luo;Hao Zhang;Zhenni Cao;Ning Cai;Yanan Xue;Faquan Yu
中科院分区：
文献类型：
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作者：
Xiaogang Luo;Hao Zhang;Zhenni Cao;Ning Cai;Yanan Xue;Faquan Yu
本研究的目的是开发透明的多孔纳米金刚石/纤维素纳米复合膜与控制释放的阿霉素作为伤口敷料的潜在应用，这是通过流延法从分散的羧化纳米金刚石和溶解纤维素均匀在7重量%的NaOH/12重量%的尿素水溶液制备。通过调节羧基化纳米金刚石的含量，得到各种纳米复合膜。通过透光率测定、扫描电镜（SEM）、傅里叶变换红外光谱（FTIR）、X射线衍射（XRD）、差示扫描量热法（DSC）、拉伸试验、失水分析等手段对膜的结构和性能进行了研究。并对膜的体外细胞毒性进行了研究。这项工作提出了一个概念验证的效用，这些膜的负载和释放的生物活性化合物被用作候选人的伤口敷料。
The objective of this study is to develop transparent porous nanodiamonds/cellulose nanocomposite membranes with controlled release of doxorubicin for potential applications as wound dressings, which were fabricated by tape casting method from dispersing carboxylated nanodiamonds and dissolving cellulose homogeneously in 7 wt% NaOH/12 wt% urea aqueous solution. By adjusting the carboxylated nanodiamonds content, various nanocomposite membranes were obtained. The structure and properties of these membranes have been investigated by light transmittance measurements, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), differential scanning calorimetry (DSC), tensile tests, water loss analyses, etc. The drug loading and release was investigated using doxorubicin hydrochloride as a model drug. In vitro cytotoxicity assay of the membranes was also studied. This work presented a proof-of-concept utility of these membranes for loading and release of bioactive compounds to be employed as a candidate for wound dressing.