Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa)
Self-reported dietary supplement use is confirmed by biological markers in the Norwegian Mother and Child Cohort Study (MoBa)
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DOI：
10.1159/000103275
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发表时间：
2007-01-01
影响因子：
3.9
通讯作者：
Meltzer, Helle Margrete
中科院分区：
文献类型：
--
作者：
Brantsaeter, Anne Lise;Haugen, Margaretha;Meltzer, Helle Margrete
背景/目标：食物频率问卷（FFQ）和膳食补充剂数据库的开发用于挪威母亲和儿童队列研究（MoBa）。本研究的目的是调查补充剂和非补充剂使用者报告的使用和生物标志物之间的关系，并验证妊娠中期自我报告的膳食补充剂摄入量。方法：从MoBa招募120名女性，119名受试者完成MoBa FFQ和4天称重食物日记。通过两种方法收集补充剂使用信息。采集静脉血标本和24小时尿样，用于测定膳食生物标志物。结果如下：维生素D、类胡萝卜素、叶酸、n - 6/ n - 3脂肪酸比和碘的补充剂和非补充剂使用者之间的生物标志物浓度/排泄和摄入量存在显著差异（所有变量p < 0.05）。补充类黄酮者的黄嘌呤排泄量高于补充类黄酮者（p < 0.05）.总膳食摄入量与（食物和补充剂）生物标志物浓度/排泄发现维生素D（r = 0.45，p < 0.001）、叶酸（r = 0.26，p = 0.005）、n - 6/ n - 3脂肪酸比率（r = 0.36，p < 0.001）和碘（r = 0.42，p < 0.001）。结论：在这项研究中检查的生化指标证实了补充剂和非补充剂使用者之间自我报告的维生素D、β-胡萝卜素、叶酸、n - 3脂肪酸、类黄酮和碘等微量营养素摄入量的差异。版权所有（c）2007 S. Karger AG，巴塞尔
Background/ Aims: A food frequency questionnaire ( FFQ) and a database for dietary supplements were developed for use in the Norwegian Mother and Child Cohort Study ( MoBa). The aim of the present study was to investigate the relation between reported use and biomarkers in supplement and nonsupplement users and to validate self- reported intake of dietary supplements in mid pregnancy. Method: 120 women were recruited from MoBa, and 119 subjects completed the MoBa FFQ and a 4- day weighed food diary. Information on supplement use was collected by both methods. Venous blood specimens and 24- hour urine samples were obtained for measurement of dietary biomarkers. Results: Biomarker concentration/ excretion and intake differed significantly between supplement and nonsupplement users for vitamin D, carotenoids, folate, the n - 6/ n - 3 fatty acid ratio and iodine ( p < 0.05 for all variables). Flavonoid excretion was higher in flavonoid- supplement users ( p < 0.05). Significant correlations between total dietary intake ( food and supplements) biomarker concentration/ excretion were found for vitamin D ( r = 0.45, p < 0.001), folate ( r = 0.26, p = 0.005), the n - 6/ n - 3 fatty acid ratio ( r = 0.36, p < 0.001) and iodine ( r = 0.42, p < 0.001). Conclusion: The biochemical indicators examined in this study confirmed differences in self- reported micronutrient intake between supplement and nonsupplement users for vitamin D, beta- carotene, folate, n - 3 fatty acids, flavonoids and iodine. Copyright (c) 2007 S. Karger AG, Basel