The effect of dietary patterns on estimated coronary heart disease risk: results from the Dietary Approaches to Stop Hypertension (DASH) trial.
The effect of dietary patterns on estimated coronary heart disease risk: results from the Dietary Approaches to Stop Hypertension (DASH) trial.
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DOI：
10.1161/circoutcomes.109.930685
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发表时间：
2010-09
期刊：
影响因子：
--
通讯作者：
Appel LJ
中科院分区：
文献类型：
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作者：
Chen ST;Maruthur NM;Appel LJ
2005年美国膳食指南中推荐了停止高血压的饮食方法（DASH）。为了了解DASH对冠心病（CHD）的潜在益处，我们使用DASH试验的数据，应用Fragrance风险方程计算10年发生CHD的风险。在DASH试验中，459名患有高血压前期或1期高血压但未服用降压药物的个体被随机分配到3种饮食中的一种：对照，水果和蔬菜（F/V）或DASH（富含水果，蔬菜，低脂乳制品，减少脂肪和胆固醇）。重量保持不变。估计的10年CHD风险是次要分析的主要结果。在436名具有完整数据的参与者中，平均（SD）年龄为44.7（10.7）岁，51%为男性，60%为非洲裔美国人。基线时的中位10年CHD风险为0.98%，并且在所有组中均降低。与对照组相比，F/V组8周与基线10年CHD风险的相对风险比为0.93（95%置信区间，0.85至1.02; P=0.12），DASH组为0.82（95%置信区间，0.75至0.90; P<0.001）。比较DASH与F/V，相对风险比为0.89（95%置信区间，0.81至0.97; P=0.012）。除了饮食模式和种族之间的相互作用表明黑人比白人风险降低更大（相互作用P =0.038）外，各亚组的结果相似。与对照组和F/V组相比，DASH饮食分别将10年CHD风险降低了18%和11%。除了降低血压外，DASH饮食还可以大大降低冠心病的风险。URL：http://clinicaltrials.gov。唯一标识符：NCT 00000544。
The Dietary Approaches to Stop Hypertension (DASH) diet is recommended in the 2005 US Dietary Guidelines. To understand the potential benefits of DASH on coronary heart disease (CHD), we applied the Framingham risk equations to calculate 10-year risk of developing CHD using data from the DASH trial. In the DASH trial, 459 individuals with prehypertension or stage-1 hypertension not taking antihypertensive medication were randomly assigned to 1 of 3 diets: control, fruits and vegetables (F/V), or DASH (rich in fruits, vegetables, low-fat dairy, and reduced in fats and cholesterol). Weight was held constant. Estimated 10-year CHD risk was the primary outcome of this secondary analysis. Among 436 participants with complete data, mean (SD) age was 44.7 (10.7) years, 51% were male, and 60% were African-American. Median 10-year CHD risk was 0.98% at baseline and decreased in all groups. Compared with control, the relative risk ratio comparing 8-week with baseline 10-year CHD risk was 0.93 (95% confidence interval, 0.85 to 1.02; P=0.12) for F/V and 0.82 (95% confidence interval, 0.75 to 0.90; P<0.001) for DASH. Comparing DASH with F/V, the relative risk ratio was 0.89 (95% confidence interval, 0.81 to 0.97; P=0.012). With the exception of an interaction between dietary pattern and race suggesting a greater risk reduction in blacks than whites (P for interaction=0.038), results were similar across subgroups. Compared with control and F/V, the DASH diet reduced estimated 10-year CHD risk by 18% and 11%, respectively. In addition to reducing blood pressure, the DASH diet should substantially reduce the risk of CHD. URL: http://clinicaltrials.gov. Unique identifier: NCT00000544.