Designing biomaterials based on biomineralization of bone
Designing biomaterials based on biomineralization of bone
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DOI：
10.1039/b910960a
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发表时间：
2010-01-01
影响因子：
--
通讯作者：
Mano, J. F.
中科院分区：
文献类型：
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作者：
Alves, N. M.;Leonor, I. B.;Mano, J. F.
在自然界中，生物体利用有机界面作为模板来控制晶体的成核和生长。在过去的几十年里，科学家们一直试图从自然界中学习如何设计受骨和其他天然矿化组织分层复杂结构启发的仿生生物材料，或控制生物矿化过程到生物材料基质上，以促进植入式装置的骨传导性能。合成骨类似物的设计，即具有与骨相似的结构和性能，必将构成骨组织工程的重大突破。此外，文献中提出了许多策略来开发生物活性骨样材料，例如使用生物活性眼镜。为了提出新的方法来改善生物材料表面的钙化或开发可用于再生医学的生物活性三维模板，生物矿化的基本方面可能也很重要。特别是，一些化学基团和蛋白质，以及发生钙化的三维基质，对羟基磷灰石的成核和生长起着根本的作用。本文将对所有这些不同的方面进行回顾和讨论。
In nature, organisms control crystal nucleation and growth using organic interfaces as templates. Scientists, in the last decades, have tried to learn from nature how to design biomimetic biomaterials inspired by the hierarchical complex structure of bone and other natural mineralised tissues or to control the biomineralization process onto biomaterials substrates to promote the osteoconductive properties of implantable devices. The design of synthetic bone analogues, i.e., with a structure and properties similar to bone, would certainly constitute a major breakthrough in bone tissue engineering. Moreover, many strategies have been proposed in the literature to develop bioactive bone-like materials, for instance using bioactive glasses. Fundamental aspects of biomineralization may be also important in order to propose new methodologies to improve calcification onto the surface of biomaterials or to develop bioactive tridimensional templates that could be used in regenerative medicine. In particular, it has been shown that some chemical groups and proteins, as well as the tridimensional matrix in which calcification would occur, play a fundamental role on the nucleation and growth of hydroxyapatite. All these distinct aspects will be reviewed and discussed in this paper.