The influence of chemotherapy-induced neurotoxicity on psychological distress and sleep disturbance in cancer patients
The influence of chemotherapy-induced neurotoxicity on psychological distress and sleep disturbance in cancer patients
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DOI：
10.3747/co.21.1984
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发表时间：
2014-08-01
期刊：
影响因子：
2.6
通讯作者：
Wu, L. H.
中科院分区：
文献类型：
--
作者：
Hong, J. S.;Tian, J.;Wu, L. H.
PurposeIn本研究，我们旨在探讨化疗引起的周围神经毒性（CIPN）对癌症患者心理困扰和睡眠质量的影响。在治疗的第4周，使用患者神经毒性问卷（PNQ）测量患者CIPN。采用匹兹堡睡眠质量指数（PSQI）、痛苦温度计（DT）和医院焦虑抑郁量表（HADS）测量患者的睡眠质量和心理痛苦。多元Logistic回归分析，以确定独立的影响，CIPN对心理困扰和睡眠障碍的patients.ResultsThese相关系数获得：0.387 PNQ总分与DT评分之间有显著性差异（p < 0.0001），0.386 PNQ总分与HADS抑郁评分之间的差异为0.379（p < 0.0001），PNQ总分与HADS焦虑评分之间的差异为0.379（p < 0.0001），PNQ总分与PSQI总体评分之间的差异为0.399（p < 0.0001）。五个PNQ等级中的苦恼、抑郁、焦虑和睡眠质量差的患病率差异有统计学意义（p < 0.0001）。在控制了年龄、性别、文化程度、社会支持、疲劳、疾病分期和肿瘤部位后，发现PNQ评分与抑郁有关（p < 0.0001），焦虑（p < 0.0001），睡眠质量差（p < 0.0001）。诱导的周围神经毒性对化疗癌症患者的心理困扰和睡眠质量产生负面影响。高PNQ等级与心理状况和睡眠质量差显著相关。我们的研究结果强调了在化疗期间评估周围神经病变和根据评估结果调整治疗计划的重要性。
PurposeIn the present study, we aimed to investigate the effects of chemotherapy-induced peripheral neurotoxicity (CIPN) on psychological distress and sleep quality in cancer patients.MethodsA total of 706 cancer patients were interviewed for the study. In the 4th week of treatment, patient CIPN was measured using the Patient Neurotoxicity Questionnaire (PNQ). The sleep quality and psychological distress of patients were measured using the Pittsburgh Sleep Quality Index (PSQI), the Distress Thermometer (DT), and the Hospital Anxiety and Depression Scale (HADS). Multiple logistic regression was applied to determine the independent effects of CIPN on psychological distress and sleep disturbance in the patients.ResultsThese correlation coefficients were obtained: 0.387 (p < 0.0001) between the PNQ total score and the DT score, 0.386 (p < 0.0001) between the PNQ total score and the HADS Depression score, 0.379 (p < 0.0001) between the PNQ total score and the HADS Anxiety score, and 0.399 (p < 0.0001) between the PNQ total score and the PSQI global score. The prevalence rates of distress, depression, anxiety, and poor sleep quality in the five PNQ grades were statistically significantly different (p < 0.0001). After controlling for age, sex, education level, social supports, fatigue, disease stage, and tumour site, the PNQ grades were found to be associated with depression (p < 0.0001), anxiety (p < 0.0001), and poor sleep quality (p < 0.0001).ConclusionsChemotherapy-induced peripheral neurotoxicity negatively affects psychological distress and sleep quality in cancer patients treated with chemotherapy. High PNQ grades were significantly associated with poor psychological status and sleep quality. Our results emphasize the importance of assessing peripheral neuropathies during chemotherapy and of adjusting treatment plans based on assessment results.