Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.
Perfluorooctanesulfonate and other fluorochemicals in the serum of American Red Cross adult blood donors.
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美国红十字会成人献血者的血清中的全氟辛磺酸盐和其他氟化物。
DOI：
10.1289/ehp.6316
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发表时间：
2003-12
影响因子：
10.4
通讯作者：
Zobel, Larry R
中科院分区：
文献类型：
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作者：
Olsen, Geary W;Church, Timothy R;Miller, John P;Burris, Jean M;Hansen, Kristen J;Lundberg, James K;Armitage, John B;Herron, Ross M;Medhdizadehkashi, Zahra;Nobiletti, John B;O'Neill, E Mary;Mandel, Jeffrey H;Zobel, Larry R
基于全氟辛烷磺酰氟的产品包括表面活性剂、纸张和包装处理剂以及表面保护剂（例如，用于地毯、室内装潢、纺织品）。取决于具体的功能衍生或聚合程度，此类产品可能会降解或代谢为全氟辛烷磺酸（PFOS），其降解或代谢程度尚未确定，全氟辛烷磺酸是一种稳定持久的最终产品，具有生物累积潜力。在这项调查中，使用高效液相色谱-电喷雾串联质谱法分析了来自六个美国红十字会血液采集中心的645份成年献血者血清样本中的全氟辛烷磺酸和其他六种含氟化合物。全氟辛烷磺酸的浓度范围为4.1 ppb至1，656.0 ppb的定量下限，几何平均值为34.9 ppb [95%置信区间（CI），33.3-36.5]。男性的几何平均值（37.8 ppb; 95% CI，35.5-40.3）高于女性（31.3 ppb; 95% CI，30.0-34.3）。未观察到随年龄变化的实质性差异。全氟辛烷磺酸的95%容许限度估计为88.5 ppb（95%置信区间上限，100.0 ppb）。其他含氟化学品（全氟辛烷磺酰胺基乙酸N-乙酯、全氟辛烷磺酰胺基乙酸N-甲酯、全氟辛烷磺酰胺基乙酸酯、全氟辛烷磺酰胺、全氟辛酸盐和全氟己烷磺酸盐）的集中趋势大约比全氟辛烷磺酸低一个数量级。由于血清中全氟辛烷磺酸浓度与人体累积接触量相关，因此这一信息可用于风险定性。
Perfluorooctanesulfonyl fluoride-based products have included surfactants, paper and packaging treatments, and surface protectants (e.g., for carpet, upholstery, textile). Depending on the specific functional derivatization or degree of polymerization, such products may degrade or metabolize, to an undetermined degree, to perfluorooctanesulfonate (PFOS), a stable and persistent end product that has the potential to bioaccumulate. In this investigation, a total of 645 adult donor serum samples from six American Red Cross blood collection centers were analyzed for PFOS and six other fluorochemicals using HPLC-electrospray tandem mass spectrometry. PFOS concentrations ranged from the lower limit of quantitation of 4.1 ppb to 1656.0 ppb with a geometric mean of 34.9 ppb [95% confidence interval (CI), 33.3-36.5]. The geometric mean was higher among males (37.8 ppb; 95% CI, 35.5-40.3) than among females (31.3 ppb; 95% CI, 30.0-34.3). No substantial difference was observed with age. The estimate of the 95% tolerance limit of PFOS was 88.5 ppb (upper limit of 95% CI, 100.0 ppb). The measures of central tendency for the other fluorochemicals (N-ethyl perfluorooctanesulfonamidoacetate, N-methyl perfluorooctanesulfonamidoacetate, perfluorooctanesulfonamidoacetate, perfluorooctanesulfonamide, perfluorooctanoate, and perfluorohexanesulfonate) were approximately an order of magnitude lower than PFOS. Because serum PFOS concentrations correlate with cumulative human exposure, this information can be useful for risk characterization.