Cyclodepsipeptides from marine sponges: natural agents for drug research.
Cyclodepsipeptides from marine sponges: natural agents for drug research.
复制标题
DOI：
10.3390/md8030810
复制
发表时间：
2010-03-22
期刊：
影响因子：
5.4
通讯作者：
Lemmens-Gruber R
中科院分区：
文献类型：
--
作者：
Andavan GS;Lemmens-Gruber R
已经鉴定了许多来自海绵的天然产物，例如环缩酚肽。该环肽家族的结构特征包括各种不常见的氨基酸残基和独特的N-末端聚酮衍生部分。Papuamides是一类海绵衍生的环状缩酚肽的代表，包括callipeltin A、celebbide A和B、homophymine A、mirabamides、microsinosamide、neamphamide A和theopapuamides。它们被认为在体外通过抑制病毒进入而具有抗HIV-1的细胞保护活性。Jasplakinolide是海洋海绵衍生环缩肽的代表成员，包括arenastatinA、geodiamolides、homophymines、spongidepsin和theopapuamides，是体外肌动蛋白聚合的有效诱导剂。虽然肌动蛋白动力学对于肿瘤转移是必不可少的，但由于其严重的细胞毒性，没有肌动蛋白靶向药物用于临床试验。尽管如此，肌动蛋白细胞骨架仍然是抗癌药物开发的潜在目标。这些特征意味着使用环缩肽作为药物研究中的分子模型。
A number of natural products from marine sponges, such as cyclodepsipeptides, have been identified. The structural characteristics of this family of cyclic peptides include various unusual amino acid residues and unique N-terminal polyketide-derived moieties. Papuamides are representatives of a class of marine sponge derived cyclic depsipeptides, including callipeltin A, celebesides A and B, homophymine A, mirabamides, microspinosamide, neamphamide A and theopapuamides. They are thought to have cytoprotective activity against HIV-1 in vitro by inhibiting viral entry. Jasplakinolide, a representative member of marine sponge-derived cyclodepsipeptides that include arenastatin A, geodiamolides, homophymines, spongidepsin and theopapuamides, is a potent inducer of actin polymerization in vitro. Although actin dynamics is essential for tumor metasasis, no actin targeting drugs have been used in clinical trials due to their severe cytotoxicity. Nonetheless, the actin cytoskeleton remains a potential target for anti-cancer drug development. These features imply the use of cyclodepsipeptides as molecular models in drug research.
登录
查看更多内容
影响因子：
9.2
作者：
Cramer, LP
通讯作者：
Cramer, LP
影响因子：
8
作者：
Cioca, DP;Kitano, K
通讯作者：
Kitano, K
影响因子：
5.2
作者：
Ghosh, AK;Xu, XM
通讯作者：
Xu, XM
影响因子：
3.6
作者：
Calimsiz, Selcuk;Ramos, Angel I. Morales;Lipton, Mark A.
通讯作者：
Lipton, Mark A.
影响因子：
20.3
作者：
Fabian, I;Halperin, D;Tsarfaty, I
通讯作者：
Tsarfaty, I