Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
Heronamides D-F, Polyketide Macrolactams from the Deep-Sea-Derived Streptomyces sp SCSIO 03032
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Heronamides D-F，来自深海链霉菌属的聚酮大环内酰胺。
DOI：
10.1021/np400665a
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发表时间：
2014-02-01
影响因子：
5.1
通讯作者：
Zhang, Changsheng
中科院分区：
文献类型：
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作者：
Zhang, Wenjun;Li, Sumei;Zhang, Changsheng
通过改变培养条件，从深海链霉菌SCSIO 03032中分离到3个新的内酰胺类化合物——heronamides D-F（1-3）。通过广泛的质谱和核磁共振分析，并与密切相关的heronamides A-C进行比较，阐明了heronamides D-F（1-3）的平面结构。通过对(3)J（HH）值和noesi数据的详细分析，推导出1-3的相对构型。通过化学修饰和应用改进的Mosher法确定了1和2的绝对构型。这些化合物都没有表现出明显的抗菌或细胞毒活性。
Three new macrolactams, heronamides D-F (1-3), were isolated from the deep-sea-derived Streptomyces sp. SCSIO 03032 upon changing cultivation conditions. The planar structures of heronamides D-F (1-3) were elucidated by extensive MS and NMR spectroscopic analyses and comparisons with the closely related heronamides A-C. The relative configurations of 1-3 were deduced by detailed analysis of (3)J(HH) values and NOESY data. The absolute configurations of 1 and 2 were determined by chemical modifications and application of the modified Mosher's method. None of the compounds exhibited obvious antimicrobial or cytotoxic activities.