Fear of cancer recurrence among breast cancer survivors could be controlled by prudent dietary modification with polyunsaturated fatty acids
Fear of cancer recurrence among breast cancer survivors could be controlled by prudent dietary modification with polyunsaturated fatty acids
复制标题
DOI：
10.1016/j.jad.2018.12.014
复制
发表时间：
2019-02-15
影响因子：
6.6
通讯作者：
Matsuoka, Yutaka J.
中科院分区：
文献类型：
--
作者：
Okubo, Ryo;Noguchi, Hiroko;Matsuoka, Yutaka J.
背景资料：癌症复发恐惧（FCR）是癌症幸存者最主要的未满足的心理需求，其病理生理学可能涉及恐惧记忆的功能失调。n-3多不饱和脂肪酸（PUFA）对精神障碍（包括抑郁症和焦虑症）具有有益作用，并且涉及恐惧记忆处理。我们假设，n-3 PUFA的组成与FCR在癌症survivor.Methods：我们进行了一项横断面研究，以检查n-3 PUFA和FCR之间的关系乳腺癌幸存者。被诊断患有浸润性乳腺癌并且没有接受化疗的成年人被要求参加。用毛细血管血评价血液PUFA组成。我们直接管理的关注复发量表（汽车），以评估FCR.Results的等级：在126名参与者用于分析，平均年龄（SD）为58（11）岁，47%的I期癌症。控制可能的混杂因素、抑郁症状和创伤后应激障碍（PTSD）症状的多元回归分析显示，α-亚麻酸（ALA）水平与汽车总体恐惧指数的平均得分显著负相关（β =-0.165，p=0.04）。没有显着的协会被发现为其他PUFAS.Limitations：我们的研究结果是从一个横断面研究在一个单一institute.Conclusion：这些研究结果提供了第一个证据的ALA对FCR的有益影响，并表明需要前瞻性研究这种关联。乳腺癌幸存者中的FCR可能是可控的谨慎选择含ALA的食用油。
Background: The pathophysiology of fear of cancer recurrence (FCR), the leading unmet psychological need of cancer survivors, may involve the dysfunctional processing of fear memory. n-3 polyunsaturated fatty acids (PUFAs) have beneficial effects on psychiatric disorders, including depressive disorder and anxiety disorders, and are involved in fear memory processing. We hypothesized that n-3 PUFA composition is associated with FCR in cancer survivors.Methods: We conducted a cross-sectional study to examine the relationship between n-3 PUFAs and FCR among breast cancer survivors. Adults who had been diagnosed with invasive breast cancer and were not undergoing chemotherapy were asked to participate. Blood PUFA composition was evaluated by using capillary blood. We directly administered the Concerns About Recurrence Scale (CARS) to assess the grade of FCR.Results: Among 126 participants used for the analysis, the mean age (SD) was 58 (11) years and 47% had stage I cancer. Multiple regression analysis controlling for possible confounders, depressive symptoms, and post-traumatic stress disorder (PTSD) symptoms revealed that the alpha-linolenic acid (ALA) level was significantly inversely associated with the average score on the CARS overall fear index (beta=-0.165, p=0.04). No significant associations were found for other PUFAs.Limitations: Our findings were obtained from a cross-sectional study in a single institute.Conclusion: These findings provide the first evidence of a beneficial effect of ALA on FCR and indicate the need for prospective study of this association. FCR among breast cancer survivors might be controllable by prudent selection of ALA-containing cooking oil.