Organocatalytic synthesis of β-enaminyl radicals as the single-electron donors for phenyliodine(III) dicarboxylates: Direct one-pot alkylation-aminoxidation of styrenes
Organocatalytic synthesis of β-enaminyl radicals as the single-electron donors for phenyliodine(III) dicarboxylates: Direct one-pot alkylation-aminoxidation of styrenes
复制标题
有机催化合成β-烯氨基自由基作为苯碘(III)二羧酸盐的单电子供体：苯乙烯的直接一锅烷基化-氨氧化
DOI：
10.1039/d2ob01826h
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发表时间：
2023
影响因子：
3.2
通讯作者：
Zhao, John C.-G.
中科院分区：
文献类型：
--
作者：
Sakkani, Nagaraju;Jha, Dhiraj Kumar;Sadiq, Nouraan;Zhao, John C.-G.
利用原位生成的烷基自由基和n -氧自由基，实现了苯乙烯衍生物的直接一锅烷基化氨基氧化反应。得到了相应的o -烷基化羟胺衍生物，收率中高。该反应的特点是苯基吡啶（III）二羧酸盐通过有机催化过程生成烷基自由基，苯基吡啶（III）二羧酸盐作为烷基自由基的来源和生成n -氧自由基的氧化剂，以及通过HAT过程生成第一代β-氨基基自由基并将其作为单电子供体使用。
A direct one-pot alkylation–aminoxidation of styrene derivatives was achieved using in situ-generated alkyl and N-oxyl radicals. The corresponding O-alkylated hydroxylamine derivatives were obtained in moderate to good yields. The reaction features the generation of the alkyl radicals from phenyliodine(III) dicarboxylates via an organocatalytic process, the use of phenyliodine(III) dicarboxylates as the source of the alkyl radicals and oxidants for the generation of N-oxyl radicals, and the first generation of the β-enaminyl radicals via a HAT process and their use as single-electron donors.