INFERRING PHYLOGENIES FROM DNA-SEQUENCES OF UNEQUAL BASE COMPOSITIONS
INFERRING PHYLOGENIES FROM DNA-SEQUENCES OF UNEQUAL BASE COMPOSITIONS
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DOI：
10.1073/pnas.92.24.11317
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发表时间：
1995-11-21
影响因子：
11.1
通讯作者：
GOUY, M
中科院分区：
文献类型：
--
作者：
GALTIER, N;GOUY, M
提出了一种计算DNA序列间进化距离的新方法。与经典方法相比，基本模型不假设序列碱基组成（A，C，G和T含量）处于平衡状态，因此允许比较序列之间的碱基组成不相等。这使得该方法比通常的方法更有效地从序列数据中恢复系统发育树时，数据集内的碱基组成是异质的，我们通过使用模拟和经验数据。当应用于小亚基核糖体RNA序列从几个原核或真核生物，这种方法提供了证据的微孢子虫Vairimorpha necatrix在真核谱系的早期分歧。
A new method for computing evolutionary distances between DNA sequences is proposed. Contrasting with classical methods, the underlying model does not assume that sequence base compositions (A, C, G, and T contents) are at equilibrium, thus allowing unequal base compositions among compared sequences. This makes the method more efficient than the usual ones in recovering phylogenetic trees from sequence data when base composition is heterogeneous within the data set, as we show by using both simulated and empirical data. When applied to small-subunit ribosomal RNA sequences from several prokaryotic or eukaryotic organisms, this method provides evidence for an early divergence of the microsporidian Vairimorpha necatrix in the eukaryotic lineage.