Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
Optimization of Cas9 RNA sequence to reduce its unexpected effects as a microRNA sponge
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DOI：
10.1186/s12943-022-01604-x
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发表时间：
2022
期刊：
影响因子：
37.3
通讯作者：
Yue Wang
中科院分区：
文献类型：
--
作者：
Junfeng Jiang;Tao Zeng;Li Zhang;Xingfei Fan;Qishu Jin;Haitao Ni;Yusheng Ye;Lipeng Cheng;Li Li;Liujun Wang;Sha Xu;Yu Yang;Juan Gu;Bing Guo;Lei Wang;Xin Li;Yingyi Qin;Jiaxi Li;Jinjiang Wang;Xi Chen;Minjuan Wu;Qi-long Ying;Xingjun Qin;Yefei Wang;Yue Wang
Cas9 RNA functions as a miRNA sponge. Let‑7 is the dominant regulated miRNA by Cas9 RNA. RNA sequence optimization of Cas9 by synonymous mutation improves its safety
