SYMPATHOADRENAL ACTIVITY AND HYPOGLYCEMIA IN THE HIBERNATING GARDEN DORMOUSE
SYMPATHOADRENAL ACTIVITY AND HYPOGLYCEMIA IN THE HIBERNATING GARDEN DORMOUSE
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DOI：
10.1016/0031-9384(90)90227-u
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发表时间：
1990-12-01
影响因子：
2.9
通讯作者：
AMBID, L
中科院分区：
文献类型：
--
作者：
ATGIE, C;NIBBELINK, M;AMBID, L
冬眠的花园睡鼠在冬眠前期是自发性的低吞噬，在这个时候，我们发现了一个低的外周交感神经活动（S.A.）。 这项工作的目的是调查膳食摄入量和SA之间的联系。 冲锋队通过HPLC测定血浆和肾上腺中的儿茶酚胺来评价。在冬眠期的再进入阶段，测量摄食量、体重、能量消耗和血糖。 结果表明：动物的能量摄入（55 ~ 83 kJ/24 h/100 g体重）低于能量消耗（145 ~ 97 kJ/24 h/100 g体重）。 能量不足在体温过低开始之前立即诱导明显的低血糖（117 mg/dl vs. 76 mg/dl），并导致外周交感神经系统急剧下降。 这反过来又减少了能量的产生，导致体温过低。
The hibernating garden dormouse is spontaneously hypophagic during the prehibernating period at which time we found a low peripheral sympathetic activity (S.A.). The aim of this work was to investigate the link between dietary intake and S.A. The S.A. was evaluated by measurement of catecholamines in both plasma and adrenal glands by HPLC. Food intake, body weight, energy expenditure and plasma glucose were measured during the reentry phase of the hibernating period. The following results were obtained: the energy intake in pretorpid animals (55 to 83 kJ/24 h/100 g body weight) was less than energy expenditure which was between 145 and 97 kJ/24 h/100 g. The energy deficit induces marked hypoglycemia immediately before the onset of hypothermia (117 mg/dl vs. 76 mg/dl) and leads to a drastic drop in the peripheral sympathetic system. This, in turn, reduced energy production, causing the hypothermia.