The Role of Medial Temporal Lobe Regions in Incidental and Intentional Retrieval of Item and Relational Information in Aging.
The Role of Medial Temporal Lobe Regions in Incidental and Intentional Retrieval of Item and Relational Information in Aging.
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DOI：
10.1002/hipo.22578
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发表时间：
2016-06
期刊：
影响因子：
3.5
通讯作者：
Giovanello KS
中科院分区：
文献类型：
--
作者：
Wang WC;Giovanello KS
大量的神经心理学和神经影像学研究表明，内侧颞叶对项目记忆和关系记忆的提取都至关重要。然而，仍有悬而未决的问题，在文献中，即内侧颞叶区域的差异招募在偶然和故意检索项目和关系信息的程度，以及在何种程度上老化可能会影响这些神经基板。目前的功能磁共振成像研究试图解决这些问题;参与者偶然编码嵌入在句子中的单词对和偶然项目和关系检索通过快速阅读完整的，重新排列的，和新的单词对句子进行评估，而故意项目和关系检索通过旧/新的联想识别一组单独的完整的，重新排列的，和新词对进行评估。结果表明，在年轻人和老年人，前海马和嗅周皮质索引偶然和故意项目检索以相同的方式。相比之下，后海马支持偶然和故意的关系检索在两个年龄组和相邻的集群在后海马招募两种形式的关系检索老年人，但不是年轻的，成年人。我们的研究结果表明，虽然内侧颞叶区域不区分偶然和有意的检索形式，有不同的作用，前和后内侧颞叶区域在检索项目和关系信息，分别，并进一步表明，在某些条件下，后区可能会过度招募在健康老龄化。
Considerable neuropsychological and neuroimaging work indicates that the medial temporal lobes are critical for both item and relational memory retrieval. However, there remain outstanding issues in the literature, namely the extent to which medial temporal lobe regions are differentially recruited during incidental and intentional retrieval of item and relational information, and the extent to which aging may affect these neural substrates. The current fMRI study sought to address these questions; participants incidentally encoded word pairs embedded in sentences and incidental item and relational retrieval were assessed through speeded reading of intact, rearranged, and new word-pair sentences, while intentional item and relational retrieval were assessed through old/new associative recognition of a separate set of intact, rearranged, and new word pairs. Results indicated that, in both younger and older adults, anterior hippocampus and perirhinal cortex indexed incidental and intentional item retrieval in the same manner. In contrast, posterior hippocampus supported incidental and intentional relational retrieval in both age groups and an adjacent cluster in posterior hippocampus was recruited during both forms of relational retrieval for older, but not younger, adults. Our findings suggest that while medial temporal lobe regions do not differentiate between incidental and intentional forms of retrieval, there are distinct roles for anterior and posterior medial temporal lobe regions during retrieval of item and relational information, respectively, and further indicate that posterior regions may, under certain conditions, be over-recruited in healthy aging.