VISUAL DEPTH PERCEPTION IN NORMAL AND DEPRIVED RATS: EFFECTS OF ENVIRONMENTAL ENRICHMENT
VISUAL DEPTH PERCEPTION IN NORMAL AND DEPRIVED RATS: EFFECTS OF ENVIRONMENTAL ENRICHMENT
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DOI：
10.1016/j.neuroscience.2013.01.036
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发表时间：
2013-04-16
期刊：
影响因子：
3.3
通讯作者：
Maffei, L.
中科院分区：
文献类型：
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作者：
Baroncelli, L.;Braschi, C.;Maffei, L.
立体功能的适当成熟需要双眼视觉体验，而感官驱动活动的早期破坏可能会导致长期甚至永久性的视觉功能损伤。弱视是视觉系统疾病的典型案例，早期两眼功能不平衡会导致视力和深度感知能力的严重缺陷。在神经可塑性水平降低的同时，大脑功能恢复的潜力也会随着年龄的增长而下降。最近的证据挑战了这种传统观点，并且已经描述了增强成人大脑中经验依赖性可塑性的实验范式。在这里，我们表明，环境丰富（EE）是一种增加认知和感觉运动刺激的条件，可以在关键期结束后恢复对感觉剥夺的立体感知的经验依赖性可塑性，并将成年弱视动物的深度感知能力恢复到正常值范围内。我们的结果鼓励基于 EE 的范式的临床应用作为治疗成年弱视的干预策略。 (C) 2013 国际广播组织。由爱思唯尔有限公司出版。保留所有权利。
A proper maturation of stereoscopic functions requires binocular visual experience and early disruption of sensory-driven activity can result in long-term or even permanent visual function impairment. Amblyopia is one paradigmatic case of visual system disorder, with early conditions of functional imbalance between the two eyes leading to severe deficits of visual acuity and depth-perception abilities. In parallel to the reduction of neural plasticity levels, the brain potential for functional recovery declines with age. Recent evidence has challenged this traditional view and experimental paradigms enhancing experience-dependent plasticity in the adult brain have been described. Here, we show that environmental enrichment (EE), a condition of increased cognitive and sensory-motor stimulation, restores experience-dependent plasticity of stereoscopic perception in response to sensory deprivation well after the end of the critical period and reinstates depth-perception abilities of adult amblyopic animals in the range of normal values. Our results encourage efforts in the clinical application of paradigms based on EE as an intervention strategy for treating amblyopia in adulthood. (C) 2013 IBRO. Published by Elsevier Ltd. All rights reserved.