Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats
Omega 3 polyunsaturated fatty acid improves spatial learning and hippocampal Peroxisome Proliferator Activated Receptors (PPARα and PPARγ) gene expression in rats
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DOI：
10.1186/1471-2202-13-109
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发表时间：
2012-09-18
期刊：
影响因子：
2.4
通讯作者：
Ebrahimi, Mahdi
中科院分区：
文献类型：
--
作者：
Hajjar, Toktam;Meng, Goh Y.;Ebrahimi, Mahdi
背景资料：本研究探讨了不同n-6：n-3比例的多不饱和脂肪酸（PUFA）对大鼠空间学习能力和海马过氧化物酶体增殖物激活受体（PPARs）基因表达的影响。将30只雄性Sprague-Dawley大鼠随机分为3组，每组10只动物，并接受具有65：1、22：1或4.5：1的不同n-6：n-3 PUFA比率的实验饮食。10周后，使用Morris水迷宫测试评估动物的空间记忆。结果：降低n-6：n-3 PUFA比例可提高大鼠在Morris水迷宫实验中的认知能力，并沿着PPAR α和PPAR γ基因表达的上调。结论：通过调节n-6：n-3 PUFA的比例，可以提高大鼠海马PPAR基因的表达，从而改善大鼠的空间学习记忆能力。
Background: This study examined the effects of dietary polyunsaturated fatty acids (PUFA) as different n-6: n-3 ratios on spatial learning and gene expression of peroxisome-proliferator-activated receptors (PPARs) in the hippocampus of rats. Thirty male Sprague-Dawley rats were randomly allotted into 3 groups of ten animals each and received experimental diets with different n-6: n-3 PUFA ratios of either 65:1, 22:1 or 4.5:1. After 10 weeks, the spatial memory of the animals was assessed using the Morris Water Maze test. The expression of PPAR alpha and PPAR gamma genes were determined using real-time PCR.Results: Decreasing dietary n-6: n-3 PUFA ratios improved the cognitive performance of animals in the Morris water maze test along with the upregulation of PPAR alpha and PPAR gamma gene expression. The animals with the lowest dietary n-6: n-3 PUFA ratio presented the highest spatial learning improvement and PPAR gene expression.Conclusion: It can be concluded that modulation of n-6: n-3 PUFA ratios in the diet may lead to increased hippocampal PPAR gene expression and consequently improved spatial learning and memory in rats.