Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX.
Hijacking the DNA damage response to enhance viral replication: gamma-herpesvirus 68 orf36 phosphorylates histone H2AX.
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DOI：
10.1016/j.molcel.2007.07.005
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发表时间：
2007-07
期刊：
影响因子：
16
通讯作者：
Anyong Xie;R. Scully
中科院分区：
文献类型：
--
作者：
Anyong Xie;R. Scully
塔拉卡诺娃等人朝着澄清急性病毒感染如何引发宿主DNA损伤反应迈出了一步。(2007年)描述了一种γ疱疹病毒蛋白，它在感染过程中磷酸化组蛋白H2AX，表明该病毒主动启动并受益于宿主DNA损伤反应。
In a step toward clarifying how acute viral infections provoke the host DNA damage response, Tarakanova et al. (2007) characterized a γ-herpesvirus protein, which phosphorylates histone H2AX during infection, suggesting that the virus actively initiates and benefits from the host DNA damage response.