Physician Perceptions About Generic Drugs
Physician Perceptions About Generic Drugs
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DOI：
10.1345/aph.1p389
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发表时间：
2011-01-01
影响因子：
2.9
通讯作者：
Choudhry, Niteesh K.
中科院分区：
文献类型：
--
作者：
Shrank, William H.;Liberman, Joshua N.;Choudhry, Niteesh K.
背景：在医疗资源有限的情况下，有必要了解阻碍具有成本效益的药物使用的因素。
目的：研究医生对仿制药的看法。
方法：医生使用5点李克特量表来报告对与成本相关的药物不依从性、仿制药的疗效和质量、对使用仿制药的偏好以及发放药物样品的影响的看法。使用描述性统计来评估医生的看法，并使用逻辑回归模型来评估医生看法的预测因素。
结果：在受邀样本中，839人（30.4%）做出了回应，506人（18.3%）符合条件并被纳入最终研究人群。超过23%接受调查的医生对仿制药的疗效持负面看法，近50%的医生对仿制药的质量持负面看法，超过四分之一的医生不倾向于将仿制药作为自己或家人的一线用药。55岁以上的医生对仿制药质量持负面看法的可能性是其他医生的3.3倍，表示自己不会使用仿制药的可能性是其他医生的5.8倍，表示不会为家人推荐仿制药的可能性是其他医生的7.5倍（所有P值均<0.05）。医生报告称制药公司代表是关于仿制药上市的最常见（75%）信息来源。近一半的受访者担心免费样品可能会对后续的可负担性产生不利影响，但三分之二的受访者会提供免费样品。
结论：相当比例的医生对仿制药持负面看法，这是仿制药使用的一个潜在障碍。试图鼓励使用仿制药的支付方和政策制定者可以考虑针对年长医生开展教育活动。
BACKGROUND: With constrained health-care resources, there is a need to understand barriers to cost-effective medication use.OBJECTIVE: To study physician perceptions about generic medications.METHODS: Physicians used 5-point Likert scales to report perceptions about cost-related medication nonadherence, the efficacy and quality of generic medications, preferences for generic use, and the implications of dispensing medication samples. Descriptive statistics were used to assess physician perceptions and logistic regression models were used to evaluate predictors of physician perceptions.RESULTS: Among the invited sample, 839 (30.4%) responded and 506 (18.3%) were eligible and included in the final study population. Over 23% of physicians surveyed expressed negative perceptions about efficacy of generic drugs, almost 50% reported negative perceptions about quality of generic medications, and more than one quarter do not prefer to use generics as first-line medications for themselves or for their family. Physicians over the age of 55 years were 3.3 times more likely to report negative perceptions about generic quality, 5.8 times more likely to report that they would not use generics themselves, and 7.5 times more likely to state that they would not recommend generics for family members (p < 0.05 for all). Physicians reported that pharmaceutical company representatives are the most common (75%) source of information about market entry of a generic medication. Almost half of the respondents expressed concern that free samples may adversely affect subsequent affordability, yet two thirds of respondents provide free samples.CONCLUSIONS: A meaningful proportion of physicians expressed negative perceptions about generic medications, representing a potential barrier to generic use. Payors and policymakers trying to encourage generic use may consider educational campaigns targeting older physicians.