DNA methylation as an early diagnostic marker of cancer (Review).
DNA methylation as an early diagnostic marker of cancer (Review).
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DOI：
10.3892/br.2014.237
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发表时间：
2014-05
影响因子：
2.3
通讯作者：
Yang S
中科院分区：
文献类型：
--
作者：
Dong Y;Zhao H;Li H;Li X;Yang S
DNA甲基化是重要的表观遗传学机制之一，与真核细胞的生长、分化和转化机制密切相关。表观遗传格局的全球变化被认为是癌症的一个标志。癌症的发生和发展是通过表观遗传修饰和基因改变来调节的。启动子区域的异常甲基化是人类基因组的一种表观遗传学异常，是癌症的高度特征。在这篇综述中，我们旨在总结我们目前对表观遗传格局变化的理解，并探讨DNA和RNA甲基化在有效的分子治疗策略中的潜在应用。
DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the mechanisms underlying cell growth, differentiation and transformation in eukaryotes. Global changes in the epigenetic landscape are considered to be a hallmark of cancer. The initiation and progression of cancer are mediated through epigenetic modifications along with genetic alterations. Aberrant methylation of promoter regions is an epigenetic abnormality of the human genome that is highly characteristic of cancer. In this review, we aimed to summarize our current understanding of the alterations in the epigenetic landscape and investigate the potential use of DNA and RNA methylation in effective molecular treatment strategies.