The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices.
The Associations of Serum Uric Acid with Obesity-Related Acanthosis nigricans and Related Metabolic Indices.
复制标题
血清尿酸与肥胖相关黑棘皮病及相关代谢指标的关系
DOI：
10.1155/2017/5438157
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发表时间：
2017
影响因子：
2.8
通讯作者：
Qu S
中科院分区：
文献类型：
--
作者：
Zhu C;Cui R;Gao M;Rampersad S;You H;Sheng C;Yang P;Sheng H;Cheng X;Bu L;Qu S
目标。最近的研究表明，高尿酸血症（HUA）与高血压、血脂异常、胰岛素抵抗和代谢综合征（MetS）有关。本研究旨在探讨肥胖患者血清尿酸与黑棘皮病（AN）及相关代谢指标的关系。方法。本研究对我科411例肥胖患者的横断面研究进行分析。测量了所有参与者的体重、身体质量指数（BMI）、UA、血脂、肝功能和肾功能。分别于0、30、60、120和180 min进行口服葡萄糖耐量试验，测定血清葡萄糖、胰岛素和C肽。结果。AN组血清UA水平高于OB组。循环UA水平与BMI、血脂异常、高血压、IR和AN相关。在logistic回归分析（多变量调整）中，血清UA水平高与血清UA最高四分位数（Q4）中女性（or = 3.00, 95% CI[1.02-8.84]）和男性（or = 6.07, 95% CI [2.16-17.06]） AN的高比值比（95%置信区间[CI]）相关。结论。血清UA水平与肥胖、高血压、高血糖、高脂血症、AN等多种代谢异常呈正相关，可能是AN发生的重要危险因素；需要进一步的体外和体内证据来研究直接或间接的关系。
Objective. Recent studies have shown that hyperuricemia (HUA) is associated with hypertension, dyslipidemia, insulin resistance, and metabolic syndrome (MetS). We aimed to examine the relationship of serum UA with Acanthosis nigricans (AN) and related metabolic indices in obese patients. Methods. A cross-sectional study with 411 obese patients recruited from our department was analyzed in this study. Weight, body mass index (BMI), UA, lipid profile, liver function, and renal function were measured in all participants. Oral glucose tolerance tests were performed, and serum glucose, insulin, and C peptide were measured at 0, 30, 60, 120, and 180 min. Results. AN group had higher serum UA levels than OB group. Circulating UA levels were associated with BMI, dyslipidemia, hypertension, IR, and AN. In logistic regression analyses (multivariable‐adjusted), a high serum UA level was associated with high odds ratios (ORs) (95% confidence interval [CI]) for AN in females (ORs = 3.00 and 95% CI [1.02–8.84]) and males (ORs = 6.07 and 95% CI [2.16–17.06]) in the highest quartile (Q4) of serum UA. Conclusions. Serum UA levels were positively associated with multiple metabolic abnormalities including obesity, hypertension, hyperglycemia, hyperlipidemia, and AN and may be an important risk factor in the development of AN; further evidences in vitro and in vivo are needed to investigate the direct or indirect relationship.