Linking neural crest development to neuroblastoma pathology.
Linking neural crest development to neuroblastoma pathology.
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DOI：
10.1242/dev.200331
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发表时间：
2022-07
期刊：
影响因子：
4.6
通讯作者：
S. G. Gonzalez Malagon;Karen J. Liu
中科院分区：
文献类型：
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作者：
S. G. Gonzalez Malagon;Karen J. Liu
虽然罕见，但儿童（儿科）癌症是幼儿死亡的主要原因。与许多成人癌症不同，儿童癌症，如神经母细胞瘤（NB），是发育性疾病，很少显示遗传倾向。NB是儿童中最常见的颅外实体瘤，占儿童癌症死亡的15%。这种异质性癌症起源于未分化的神经嵴来源的祖细胞。由于神经嵴细胞具有多能性和迁移性，它们通常被认为是癌症干细胞的胚胎范例。然而，人们对触发肿瘤发生和进展的事件知之甚少。在这里，我们讨论最近的见解交感肾上腺谱系规范，以及与NB相关的遗传因素。考虑到这一点，我们认为NB的神经嵴谱系的发展轨迹的背景下的分子基础。这使我们能够比较不同亚型的疾病和基因功能的相互作用在神经嵴发育的敏感阶段。
Although rare, childhood (paediatric) cancers are a major cause of death in young children. Unlike many adult cancers, paediatric cancers, such as neuroblastoma (NB), are developmental diseases that rarely show genetic predispositions. NB is the most common extracranial solid tumour in children, accounting for ∼15% of paediatric cancer deaths. This heterogeneous cancer arises from undifferentiated neural crest-derived progenitor cells. As neural crest cells are multipotent and migratory, they are often considered the embryonic paradigm of cancer stem cells. However, very little is known about the events that trigger tumour initiation and progression. Here, we discuss recent insights into sympathoadrenal lineage specification, as well as genetic factors associated with NB. With this in mind, we consider the molecular underpinnings of NB in the context of developmental trajectories of the neural crest lineage. This allows us to compare distinct subtypes of the disease and gene-function interactions during sensitive phases of neural crest development.