Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior
Recruitment of GABAergic Interneurons in the Barrel Cortex during Active Tactile Behavior
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DOI：
10.1016/j.neuron.2019.07.027
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发表时间：
2019-10-23
期刊：
影响因子：
16.2
通讯作者：
Svoboda, Karel
中科院分区：
文献类型：
--
作者：
Yu, Jianing;Hu, Hang;Svoboda, Karel
神经计算涉及不同类型的GABA能抑制性中间神经元，它们与兴奋性（E）神经元整合成精确结构的回路。为了了解每种神经元类型如何塑造感觉表征，我们测量了桶皮质中定义类型的神经元的放电模式，同时小鼠执行主动的，胡须依赖的物体定位任务。触摸兴奋快速发放（FS）的中间神经元在短的潜伏期，随后激活E神经元和生长抑素表达（SST）的中间神经元。触摸只有弱调制血管活性肠多肽表达（VIP）的中间神经元。主动胡须运动激活腹后内侧核（VPM）靶层的FS神经元，SST神经元的一个子集和VIP神经元的大部分。FS神经元一起跟踪丘脑输入，介导前馈抑制。SST神经元监测局部兴奋，提供反馈抑制。VIP神经元被非感觉输入激活，解除E和FS神经元的抑制。我们的数据揭示了行为过程中中间神经元类型的招募规则，为理解皮层微电路中的计算提供了基础。
Neural computation involves diverse types of GABAergic inhibitory interneurons that are integrated with excitatory (E) neurons into precisely structured circuits. To understand how each neuron type shapes sensory representations, we measured firing patterns of defined types of neurons in the barrel cortex while mice performed an active, whisker-dependent object localization task. Touch excited fast-spiking (FS) interneurons at short latency, followed by activation of E neurons and somatostatin-expressing (SST) interneurons. Touch only weakly modulated vasoactive intestinal polypeptide-expressing (VIP) interneurons. Voluntary whisker movement activated FS neurons in the ventral posteromedial nucleus (VPM) target layers, a subset of SST neurons and a majority of VIP neurons. Together, FS neurons track thalamic input, mediating feedforward inhibition. SST neurons monitor local excitation, providing feedback inhibition. VIP neurons are activated by non-sensory inputs, disinhibiting E and FS neurons. Our data reveal rules of recruitment for interneuron types during behavior, providing foundations for understanding computation in cortical microcircuits.