Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle
Aberration-diverse optical coherence tomography for suppression of multiple scattering and speckle
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DOI：
10.1364/boe.9.004919
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发表时间：
2018-10-01
影响因子：
3.4
通讯作者：
Adie, Steven G.
中科院分区：
文献类型：
--
作者：
Liu, Siyang;Lamont, Michael R. E.;Adie, Steven G.
多重散射是限制散射介质中光学成像深度的主要障碍。为了减轻这种影响，我们演示了像差多样化光学相干断层扫描（AD-OCT），它利用单散射光子的确定性信号之间的相位相关性来抑制由多重散射和散斑引起的随机背景。 AD-OCT 用不同的像差点扩散函数照亮样本体积，并通过计算消除这些有意施加的像差。在累积 12 个像散不同的 OCT 体积后，我们通过来自位于厚散射层下方 7.2 散射平均自由路径的美国空军目标的重建信号的相干平均值，显示了信号与背景比的 10 dB 增强，以及散射层内重建信号的非相干平均值的 3 倍散斑对比度减少。当使用像散照明实施时，这种 AD-OCT 方法是超深体积光学相干显微镜的一种有前途的方法。 (C) 2018 年美国光学协会根据 OSA 开放获取出版协议条款
Multiple scattering is a major barrier that limits the optical imaging depth in scattering media. In order to alleviate this effect, we demonstrate aberration-diverse optical coherence tomography (AD-OCT), which exploits the phase correlation between the deterministic signals from single-scattered photons to suppress the random background caused by multiple scattering and speckle. AD-OCT illuminates the sample volume with diverse aberrated point spread functions, and computationally removes these intentionally applied aberrations. After accumulating 12 astigmatism-diverse OCT volumes, we show a 10 dB enhancement in signal-to-background ratio via a coherent average of reconstructed signals from a USAF target located 7.2 scattering mean free paths below a thick scattering layer, and a 3x speckle contrast reduction from an incoherent average of reconstructed signals inside the scattering layer. This AD-OCT method, when implemented using astigmatic illumination, is a promising approach for ultra-deep volumetric optical coherence microscopy. (C) 2018 Optical Society of America under the terms of the OSA Open Access Publishing Agreement