Resting-State BOLD MRI for Perfusion and Ischemia.
Resting-State BOLD MRI for Perfusion and Ischemia.
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DOI：
10.1097/rmr.0000000000000119
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发表时间：
2017-04
期刊：
影响因子：
--
通讯作者：
Iv M
中科院分区：
文献类型：
--
作者：
Kroll H;Zaharchuk G;Christen T;Heit JJ;Iv M
包括CT血管造影、CT灌注、MR血管造影、MR弥散和灌注加权成像在内的先进成像技术，以及最近的静息态BOLD（血氧水平依赖性）功能性MRI（rs-fMRI）越来越多地用于评估急性缺血性卒中患者。先进的成像技术可以识别缺血性卒中患者，并确定梗死和潜在可挽救组织的大小，所有这些都为适当的卒中管理提供了关键信息。此外，rs-fMRI缺血增加了信息在微血管水平，从而提高了理解受损的脑灌注和组织氧合的病理生理机制超出了已知的概念在大血管水平。因此，它可以进一步描绘功能和功能失调的神经元网络，指导中风干预，并改善预后和监测患者的结果。
Advanced imaging techniques including CT angiography, CT perfusion, MR angiography, MR with diffusion- and perfusion-weighted imaging, and, more recently, resting-state BOLD (Blood Oxygen Level Dependent) functional MRI (rs-fMRI) are increasingly used to evaluate patients with acute ischemic stroke. Advanced imaging allows for identification of patients with ischemic stroke and determination of the size of infarcted and potentially salvageable tissue, all of which yield crucial information for proper stroke management. The addition of rs-fMRI for ischemia adds information at the microvascular level, thereby improving the understanding of pathophysiologic mechanisms of impaired cerebral perfusion and tissue oxygenation beyond the known concepts at the macrovascular level. As such, it may further delineate functional and dysfunctional neuronal networks, guide stroke interventions, and improve prognosis and monitoring of patient outcomes.