Schizophrenia as a disorder of social communication.
Schizophrenia as a disorder of social communication.
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DOI：
10.1155/2012/920485
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发表时间：
2012
影响因子：
2.4
通讯作者：
Wible CG
中科院分区：
文献类型：
--
作者：
Wible CG
证据审查的存在的一个核心系统的时刻到时刻的社会沟通，是基于动态的姿势和其他社会知觉过程中的颞顶枕交界处（TPJ），包括后上级颞沟（PSTS）和周围地区的看法。这些区域的过度激活可能产生精神分裂症综合征。TPJ在感知和产生自我和他人的动态社会，情感和注意力姿态中起着关键作用。这些包括身体、面部和眼睛的动态姿势以及视听语音和韵律。许多阴性症状的特点是在这些领域内的反应缺陷。通过单神经元记录、脑刺激、神经成像和神经损伤的研究，发现了该系统的几个特性。这些特性映射到精神分裂综合征。动态手势的表征是多模态的（听觉、视觉和触觉），与精神分裂症的主要幻觉类别相匹配。手势表征的感知信号中固有的是对意图、能动性和预期或期望（对于自我和他人）的计算。神经元也被调整或偏向于快速检测与威胁相关的情绪。我回顾了这个系统过度激活可能导致精神分裂症的初步证据。
Evidence is reviewed for the existence of a core system for moment-to-moment social communication that is based on the perception of dynamic gestures and other social perceptual processes in the temporal-parietal occipital junction (TPJ), including the posterior superior temporal sulcus (PSTS) and surrounding regions. Overactivation of these regions may produce the schizophrenic syndrome. The TPJ plays a key role in the perception and production of dynamic social, emotional, and attentional gestures for the self and others. These include dynamic gestures of the body, face, and eyes as well as audiovisual speech and prosody. Many negative symptoms are characterized by deficits in responding within these domains. Several properties of this system have been discovered through single neuron recording, brain stimulation, neuroimaging, and the study of neurological impairment. These properties map onto the schizophrenic syndrome. The representation of dynamic gestures is multimodal (auditory, visual, and tactile), matching the predominant hallucinatory categories in schizophrenia. Inherent in the perceptual signal of gesture representation is a computation of intention, agency, and anticipation or expectancy (for the self and others). The neurons are also tuned or biased to rapidly detect threat-related emotions. I review preliminary evidence that overactivation of this system can result in schizophrenia.