Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans.
Loss of famh-136/ FAM136A results in minor locomotion and behavioral changes in Caenorhabditis elegans.
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DOI：
10.17912/micropub.biology.000553
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发表时间：
2022
影响因子：
--
通讯作者：
Sternberg PW
中科院分区：
文献类型：
--
作者：
Tan CH;Park H;Sternberg PW
关于FAM 136 A的了解不多，FAM 136 A是一种可能与梅尼埃病有关的人类基因，在动物中是保守的。为了理解famh-136（秀丽隐杆线虫FAM 136 A的直系同源物）的功能，产生了该基因的功能丧失等位基因。我们发现，famh-136功能的丧失会导致运动和行为发生微小但显著的变化。
Not much is known about FAM136A, a human gene that may be involved in Meniere’s disease and is conserved throughout animals. To understand the function of famh-136 , the Caenorhabditis elegans ortholog of FAM136A, loss of function alleles of the gene were generated. We find that loss of famh-136 function results in minor but significant changes to the locomotion and behavior.