Anthelmintic resistance in human helminths: a review
Anthelmintic resistance in human helminths: a review
复制标题
DOI：
10.1046/j.1365-3156.2001.00774.x
复制
发表时间：
2001-11-01
影响因子：
3.3
通讯作者：
Gryseels, B
中科院分区：
文献类型：
--
作者：
Geerts, S;Gryseels, B
我们简要回顾了有关人类蠕虫耐药性的报道，并比较了导致家畜和人对驱虫药耐药性发展的因素，即治疗频率高、单一用药方案、靶向和大规模治疗的时机以及剂量不足。从家畜蠕虫的治疗和控制中的失误中得出结论。讨论了目前家畜蠕虫抗药性检测方法的优缺点，并提出了规范人体蠕虫抗药性检测方法的建议。最后，根据兽医经验，提出了一些降低人体蠕虫耐药性发展风险的建议。对所有主要兽用驱虫剂的抗药性急剧和迅速地蔓延，应该是对蠕虫控制方案中对药物的过度依赖的警告。
We briefly review reports on drug resistance in human helminths and compare the factors which contribute to the development of anthelmintic resistance in livestock and man, i.e. high treatment frequency, single-drug regimens, targeting and timing of mass treatments and underdosing. Conclusions are drawn from the mistakes in the treatment and control of livestock helminths. The advantages and inconveniences of current methods for the detection of drug resistance in helminths of livestock are discussed and some suggestions are put forward to standardize the tests for the detection of resistance in human helminths. Finally, based on veterinary experience, some recommendations are made to reduce the risks of development of drug resistance in human helminths. The dramatic and rapid spread of resistance to all major classes of veterinary anthelmintics should be a warning against too strong a reliance on drugs in helminth control programmes.