Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients.
Pulmonary involvement during cytomegalovirus infection in immunosuppressed patients.
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DOI：
10.1034/j.1399-3062.2003.00023.x
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发表时间：
2003-09-01
期刊：
影响因子：
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通讯作者：
van Son, W J
中科院分区：
文献类型：
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作者：
de Maar, E F;Verschuuren, E A M;van Son, W J
尽管巨细胞病毒（CMV）肺部感染在实体器官移植后已不常见，但CMV肺炎仍是一种潜在的致命并发症。pp65抗原血症检测的引入使得能够在移植患者出现症状之前早期和快速诊断CMV病毒血症。此外，在无症状的CMV病毒血症患者中，可以证明肺弥散能力降低。在这篇综述中，我们讨论了临床和亚临床的CMV感染的肺部参与免疫功能低下的主机，重点是移植受者。本文讨论巨细胞病毒肺炎的临床过程、诊断、治疗、预防和病理生理学。
Although cytomegalovirus (CMV) pulmonary involvement after solid organ transplantation is infrequently seen nowadays, CMV pneumonitis is still a potential lethal complication. Introduction of the pp65 antigenemia assay enabled early and rapid diagnosis of CMV viremia in transplant patients prior to symptoms. Also, in asymptomatic patients with CMV viremia, a decreased pulmonary diffusion capacity could be demonstrated. In this review, we discuss clinical and subclinical pulmonary involvement of CMV infection in the immunocompromised host with an emphasis on transplant recipients. The clinical course, diagnosis, therapy, prophylaxis, and pathophysiology of CMV pneumonitis are discussed.