Abuse and diversion of buprenorphine sublingual tablets and film
Abuse and diversion of buprenorphine sublingual tablets and film
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DOI：
10.1016/j.jsat.2014.02.003
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发表时间：
2014-07-01
影响因子：
3.9
通讯作者：
Dart, Richard C.
中科院分区：
文献类型：
--
作者：
Lavonas, Eric J.;Severtson, S. Geoffrey;Dart, Richard C.
丁丙诺啡滥用在世界范围内很常见。比较了三种舌下丁丙诺啡制剂（单成分片剂;纳洛酮复方片剂和膜剂）的滥用率和转移率。数据来自研究性滥用、转移和成瘾相关监测（RADARS（R））系统毒物中心、药物转移、阿片类药物治疗（OTP）、关键举报人患者调查（SKIP）和大学调查计划，截至2012年12月。为了控制药物可用性，根据每种制剂的处方患者数量（“分发药物的唯一接受者”，URDD），每季度计算一次事件比率（发生率），并使用负二项回归进行平均和比较。OTP、SKIP和大学调查方案中单一成分片剂的滥用率最高，毒药中心方案中的滥用率和非法转移率最高的是复方片剂。在所有项目中，组合薄膜的发生率均显著低于任一片剂的发生率。没有地理模式可以辨别。(C)2014作者由Elsevier Company出版。这是CC BY-NC-SA许可下的开放获取文章（http：//creativecommons.org/licenses/by-nc-sa/3.0/）。
Buprenorphine abuse is common worldwide. Rates of abuse and diversion of three sublingual buprenorphine formulations (single ingredient tablets; naloxone combination tablets and film) were compared. Data were obtained from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS (R)) System Poison Center, Drug Diversion, Opioid Treatment (OTP), Survey of Key Informants' Patients (SKIP), and College Survey Programs through December 2012. To control for drug availability, event ratios (rates) were calculated quarterly, based on the number of patients filling prescriptions for each formulation ("unique recipients of a dispensed drug," URDD) and averaged and compared using negative binomial regression. Abuse rates in the OTP, SKIP, and College Survey Programs were greatest for single ingredient tablets, and abuse rates in the Poison Center Program and illicit diversion rates were greatest for the combination tablets. Combination film rates were significantly less than rates for either tablet formulation in all programs. No geographic pattern could be discerned. (C) 2014 The Authors. Published by Elsevier Company. This is an open access article under the CC BY-NC-SA license (http://creativecommons.org/licenses/by-nc-sa/3.0/).