Magnetic resonance angiography and perfusion mapping by arterial spin labeling using Fourier transform-based velocity-selective pulse trains: Examination on a commercial perfusion phantom.
Magnetic resonance angiography and perfusion mapping by arterial spin labeling using Fourier transform-based velocity-selective pulse trains: Examination on a commercial perfusion phantom.
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DOI：
10.1002/mrm.28805
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发表时间：
2021-09
影响因子：
3.3
通讯作者：
Qin Q
中科院分区：
文献类型：
--
作者：
Xu F;Zhu D;Fan H;Lu H;Liu D;Li W;Qin Q
在标准化体模上对血流和灌注 MR 技术进行基准测试可以促进在多个部位、场强和供应商之间使用先进的血管造影和灌注映射技术。在这里，使用基于傅立叶变换 (FT) 的速度选择性饱和度和反转脉冲序列的动脉自旋标记 (ASL) 进行 MRA 和灌注测绘，并在商业灌注模型上进行了评估。将基于 FT 速度选择性饱和的 MRA 和基于 FT 速度选择性反转的 ASL 灌注成像与 3 T 灌注模型上的飞行时间和伪连续 ASL 在两种受控流速（175 mL/min 和 350 mL/min）下进行比较。速度选择性 MRA (VSMRA) 和速度选择性 ASL (VSASL) 均以三个速度编码方向进行：脚-头、左-右和倾斜 45°。对 MRA 扫描和灌注加权信号的对比噪声比以及 ASL 方法的标记效率进行了量化。在这个带有仅垂直和横向流动方向的饲管的模型上，VSMRA 和 VSASL 表现出速度编码方向的依赖性。脚头编码的 VSMRA 和 VSASL 分别针对两种流速生成类似的信号对比度，如飞行时间和伪连续 ASL。倾斜 45° 编码的 VSMRA 比脚头和左右编码的 VSMRA 扫描在切片上产生更均匀的对比度噪声比。倾斜 45° 编码的 VSASL 通过对整个饲管进行更均匀的标记，将标记效率从 0.22–0.68 提高到 0.82–0.90。基于 FT 速度选择性饱和的 VSMRA 和基于 FT 速度选择性反演的 VSASL 均在商业灌注模型上进行了表征。建议仔细选择沿主要血管的速度编码方向，以用于各种器官的应用。
Benchmarking of flow and perfusion MR techniques on standardized phantoms can facilitate the use of advanced angiography and perfusion-mapping techniques across multiple sites, field strength, and vendors. Here, MRA and perfusion mapping by arterial spin labeling (ASL) using Fourier transform (FT)–based velocity-selective saturation and inversion pulse trains were evaluated on a commercial perfusion phantom. The FT velocity-selective saturation–based MRA and FT velocity-selective inversion–based ASL perfusion imaging were compared with time-of-flight and pseudo-continuous ASL at 3 T on the perfusion phantom at two controlled flow rates, 175 mL/min and 350 mL/min. Velocity-selective MRA (VSMRA) and velocity-selective ASL (VSASL) were each performed with three velocity-encoding directions: foot–head, left–right, and oblique 45°. The contrast-to-noise ratio for MRA scans and perfusion-weighted signal, as well as labeling efficiency for ASL methods, were quantified. On this phantom with feeding tubes having only vertical and transverse flow directions, VSMRA and VSASL exhibited the dependence of velocity-encoding directions. The foot–head-encoded VSMRA and VSASL generated similar signal contrasts as time of flight and pseudo-continuous ASL for the two flow rates, respectively. The oblique 45°–encoded VSMRA yielded more uniform contrast-to-noise ratio across slices than foot–head and left–right-encoded VSMRA scans. The oblique 45°–encoded VSASL elevated labeling efficiency from 0.22–0.68 to 0.82–0.90 through more uniform labeling of the entire feeding tubes. Both FT velocity-selective saturation–based VSMRA and FT velocity-selective inversion–based VSASL were characterized on a commercial perfusion phantom. Careful selection of velocity-encoding directions along the major vessels is recommended for their applications in various organs.