Fatty acid compositions of red blood cell phospholipids in children with autism
Fatty acid compositions of red blood cell phospholipids in children with autism
复制标题
DOI：
10.1016/j.plefa.2006.02.001
复制
发表时间：
2006-04-01
影响因子：
3
通讯作者：
Jin, LW
中科院分区：
文献类型：
--
作者：
Bu, B;Ashwood, P;Jin, LW
我们比较了40名孤独症儿童（20名早发性孤独症儿童和20名发育退化儿童）和年龄匹配的20名典型发育对照组和20名非孤独症发育障碍儿童红细胞膜中的脂肪酸组成，包括n-3、n-6多不饱和脂肪酸、反式和顺式单不饱和脂肪酸以及饱和脂肪酸。主要发现包括与正常发育的对照组相比，患有发育倒退的自闭症受试者的二十碳烯酸（20：1 n9）和芥酸（22：1 n9）水平升高。此外，一。与早发性自闭症儿童相比，临床消退儿童中20：2N 6增加，16：1 N7减少。我们的研究结果并没有为脂肪酸代谢异常在自闭症谱系障碍的发病机制中发挥作用的假设提供有力的证据，尽管它们表明自闭症的退行性形式中存在先天性代谢或饮食异常。(c)2006爱思唯尔有限公司保留所有权利。
We compared the compositions of fatty acids including n-3, n-6 polyunsaturated fatty acids, trans- and cis-monounsaturated fatty acids, and saturated fatty acids in the red blood cell membranes of 40 children with autism (20 with early onset autism and 20 with developmental regression) and age-matched, 20 typically developing controls and 20' subjects with non-autistic developmental disabilities. The main findings include increased levels of eicosenoic acid (20:1n9) and erucic acid (22:1n9) in autistic subjects with developmental regression when compared with typically developing controls. In addition, an. increase in 20:2n6 and a decrease in 16:1 n7t were observed in children with clinical regression compared to those with early onset autism. Our results do not provide strong evidence for the hypothesis that abnormal fatty acid metabolism plays a role in the pathogenesis of autism spectrum disorder, although they suggest Borne metabolic or dietary abnormalities in the regressive form of autism., (c) 2006 Elsevier Ltd. All rights reserved.