BONE AND CARTILAGE DIFFERENTIATION
BONE AND CARTILAGE DIFFERENTIATION
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DOI：
10.1016/0959-437x(94)90141-o
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发表时间：
1994-10-01
影响因子：
4
通讯作者：
REDDI, AH
中科院分区：
文献类型：
--
作者：
REDDI, AH
骨和软骨分化调控研究的最新进展来自编码骨形态发生蛋白（BMP）的基因的分离、克隆和表达。BMP以连续级联方式启动软骨和骨形成。它们对趋化性、有丝分裂、酸分化的多效性作用基于浓度依赖性阈值。BMP家族多个成员的存在引起了关于功能冗余的问题。目前在不同实验室进行的工作已经揭示，通过同源重组敲除BMP-2或BMP-4基因，令人惊讶地导致胚胎致死。软骨内发育过程中的软骨和骨分化涉及一系列步骤：起始、促进、维持、建模和终止。启动和维持的信号因子正在分子水平上定义，未来的研究将集中在初始信号分子如BMP的基因调控上。通过对小鼠短耳和短足症等骨骼突变的系统研究，在确定骨形成蛋白在骨发育中的作用方面取得了关键进展。这一领域的进展速度加快，预示着骨和软骨形态发生的分子基础的解决。
Recent progress in the study of regulation of bone and cartilage differentiation has come from the isolation, cloning, and expression of genes encoding bone morphogenetic proteins (BMPs). BMPs initiate cartilage and bone formation in a sequential cascade. Their pleiotropic effects on chemotaxis, mitosis, acid differentiation are based on concentration-dependent thresholds. The existence of multiple members of the BMP family raises issues concerning functional redundancy. Current work in progress in different laboratories has revealed that BMP-2 or BMP-4 gene knockout by homologous recombination results, surprisingly, in embryonic lethality. Cartilage and bone differentiation during endochondral development involves a continuum of steps: initiation, promotion, maintenance, modeling, and termination. The signaling factors for initiation and maintenance are being defined at the molecular level, and future studies will focus on the gene regulation of initial signaling molecules such as BMPs. Critical progress in the determination of the role of BMPs in bone development has been accomplished by systematic study of skeletal mutations such as short ear and brachypodism in mice. The accelerating pace of advance in this area augurs well for the resolution of the molecular basis of morphogenesis of bone and cartilage.