Distinctive sleep problems in children with perinatal moderate or mild hypoxic-ischemia
Distinctive sleep problems in children with perinatal moderate or mild hypoxic-ischemia
复制标题
围产期中度或轻度缺氧缺血儿童的独特睡眠问题
DOI：
10.1016/j.neulet.2015.12.061
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发表时间：
2016-02-12
影响因子：
2.5
通讯作者：
Feng, Xing
中科院分区：
文献类型：
--
作者：
Ding, Xin;Cheng, Zhi;Feng, Xing
围产期缺氧缺血（hypoxic-ischemia，HI）后的认知和运动功能障碍是目前研究的热点。睡眠问题，虽然报告与脑瘫（CP），往往被忽视的非严重HI患者。在这里，通过调查不同程度的HI儿童的睡眠质量，我们发现睡眠的开始和维持，睡眠相关的呼吸问题，或昼夜节律问题分别与中度或轻度HI儿童高度相关。对2岁患者的随访MRI研究显示，脑室周围白色病变包括脑室周围白质软化（PVL）在中度HI儿童中普遍存在，但在轻度HI儿童中不常见。与此相反，松果体囊肿的发生在轻度HI的儿童有很高的风险。我们的研究提供了新的见解与不同程度的HI儿童相关的独特的睡眠问题的机制，因此，揭示了有针对性的治疗方法的研究，睡眠障碍的儿童谁患有HI。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Extensive studies focus on the cognitive and motor impairments after perinatal hypoxic-ischemia (HI). Sleep problems, although reported to be associated with cerebral palsy (CP), are often overlooked in non-severe HI patients. Here, by investigating the sleep qualities of children with different degrees of HI, we discovered that sleep initiation and maintenance, sleep-related breathing problems, or circadian rhythmic issues were highly associated with children of moderate or mild HI, respectively. Follow-up MRI studies in 2-year old patients showed that periventricular white matter lesions including periventricular leukomalacia (PVL) were prevalent in moderate, but not mild, HI children. In contrast, the occurrence of pineal cysts had a high risk in children with mild HI. Our study provides novel insights into the mechanisms of distinctive sleep problems associated with children of different degrees of HI, and therefore sheds light on the studies of targeted therapeutic treatments for sleep disorders in children who suffer from HI. (C) 2016 Elsevier Ireland Ltd. All rights reserved.