Event-related potentials in psychiatry: differentiating depression and dementia in the elderly.
Event-related potentials in psychiatry: differentiating depression and dementia in the elderly.
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精神病学中的事件相关电位：区分老年人的抑郁症和痴呆症。
DOI：
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发表时间：
1982
期刊：
影响因子：
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通讯作者：
A. Larue
中科院分区：
文献类型：
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作者：
W. Brown;J. T. Marsh;A. Larue
对25例老年抑郁症患者和26例正常对照者进行事件相关电位（ERPs）检测，以探讨ERPs对老年抑郁症和痴呆的鉴别诊断价值。采用两种ERP测量方法：（1）P300潜伏期，（2）N1波幅增加14 dB的音调强度增加（即强度增加-降低）。虽然增加-减少被证明没有什么好处，但P300潜伏期与简易精神状态（MMS）评分高度相关，并正确识别了18名痴呆患者中的10名。7名精神疾病患者（主要是抑郁症）或26名正常人中没有一人被错误分类。P300潜伏期和MMS评分的联合使用能更好地区分抑郁症和痴呆。
Event-related potentials (ERPs) were recorded from 25 elderly patients and 26 normal controls to determine whether ERPs can aid in the differential diagnosis of depression and dementia. Two ERP measures were used: (1) P300 latency, and (2) N1 amplitude increase for a 14db tone intensity increase (i.e. intensity augmenting-reducing). While augmenting-reducing proved of little benefit, P300 latency was highly correlated with Mini-Mental State (MMS) scores and correctly identified 10 of 18 demented patients. None of the seven patients with psychiatric disorders (primarily depression) or 26 normals were misclassified. Better differentiation of depression and dementia resulted from combined use of P300 latency and MMS scores.