Major histocompatibility complex molecules on parenchymal cells of the target organ protect against autoimmune disease.
Major histocompatibility complex molecules on parenchymal cells of the target organ protect against autoimmune disease.
复制标题
靶器官实质细胞上的主要组织相容性复合物分子可预防自身免疫性疾病。
DOI：
10.1159/000099260
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发表时间：
2007
期刊：
影响因子：
--
通讯作者：
Sun,Deming
中科院分区：
文献类型：
--
作者：
Shao,Hui;Kaplan,HenryJ;Sun,Deming
在疾病过程中，自身免疫器官的实质细胞可能仅表达主要组织相容性复合物（MHC）分子。在本文中，我们假设，实质细胞上的MHC分子的外观可能会增加入侵的自身反应性T细胞的激活，并加剧或抑制局部炎症。据推测，像许多生物反应一样，这是一把双刃剑，即适度水平的MHC分子表达可能抑制入侵T细胞的活化，而这些分子的过度表达可能促进自身免疫T细胞的活化，增强炎症级联反应，从而导致组织损伤。
Parenchymal cells of the autoimmune organ may only express major histocompatibility complex (MHC) molecules during the disease process. In this paper, we hypothesize that the appearance of MHC molecules on parenchymal cells may augment the activation of invading autoreactive T cells and either exacerbate or suppress local inflammation. It is speculated that like many biological responses this is a two-edge sword–namely, the expression of modest levels of MHC molecules may inhibit the activation of invading T cells, whereas overexpres-sion of these molecules may promote activation of autoimmune T cells, enhancing the inflammatory cascade, thus leading to tissue damage.