T-regulatory cells: key players in tumor immune escape and angiogenesis.
T-regulatory cells: key players in tumor immune escape and angiogenesis.
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DOI：
10.1158/0008-5472.can-11-3687
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发表时间：
2012-05-01
期刊：
影响因子：
11.2
通讯作者：
Coukos G
中科院分区：
文献类型：
--
作者：
Facciabene A;Motz GT;Coukos G
在多种肿瘤类型中都发现调节性 T 细胞 (Treg) 浸润肿瘤，而肿瘤浸润性 T 细胞通常与不良的临床结果相关。 Tregs 是免疫系统中有效的免疫抑制细胞，通过限制抗肿瘤免疫和促进血管生成的能力来促进癌症的进展。在这里，我们讨论Tregs抑制抗肿瘤免疫反应的方式，并详细阐述我们最近发现的Tregs对肿瘤血管生成做出重要的直接贡献。此外，我们重点介绍了目前几种旨在消除癌症患者体内 Tregs 的疗法。鉴于 Tregs 在癌症中的多方面作用，对其功能的更深入了解将最终增强未来的治疗方法。
Regulatory T cells (Tregs) are found infiltrating tumors in a vast array of tumor types, and tumor-infiltrating Tregs are often associated with a poor clinical outcome. Tregs are potent immunosuppressive cells of the immune system that promote progression of cancer through their ability to limit antitumor immunity and promote angiogenesis. Here, we discuss the ways in which Tregs suppress the antitumor immune response, and elaborate on our recent discovery that Tregs make significant direct contributions to tumor angiogenesis. Further, we highlight several current therapies aimed at the elimination of Tregs within cancer patients. Given the multifaceted role of Tregs in cancer, a greater understanding of their functions will ultimately strengthen future therapies.