Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study
Chronic rhinosinusitis in Europe - an underestimated disease. A GA2LEN study
复制标题
DOI：
10.1111/j.1398-9995.2011.02646.x
复制
发表时间：
2011-09-01
期刊：
影响因子：
12.4
通讯作者：
Burney, P.
中科院分区：
文献类型：
--
作者：
Hastan, D.;Fokkens, W. J.;Burney, P.
背景：慢性鼻-鼻窦炎(CRS)是一种常见的健康问题，具有巨大的医疗费用和对一般健康的影响。即便如此，我们仍无法获得欧洲的患病率数据。在这项由GA(2)LEN卓越网络进行的研究中，应用欧洲鼻窦炎和鼻息肉(EPOS-O-3)诊断标准来估计欧洲人慢性鼻-鼻窦炎(CRS)患病率的差异。方法：邮寄问卷调查欧洲19个中心1575岁的成年人。参与者报告了CRS的症状，医生诊断为CRS、过敏性鼻炎、年龄、性别和吸烟史。CRS的定义是基于(EPOS)-O-3诊断标准：存在两种以上的症状：(I)鼻塞，(Ii)鼻分泌物，(Iii)面部疼痛/压力或(Iv)嗅觉减退，在过去的12周内--至少有一种症状是鼻塞或排出物。结果：来自12个国家19个中心的57128名应答者的信息。根据(EPOS)-O-3标准，CRS的总患病率为10.9%(范围为6.9-27.1)。CRS在吸烟者中比不吸烟者更常见(OR 1.7：95%CI 1.6-1.9)。中心内自行报告的医生诊断的CRS的患病率与(EPOS)-O-3诊断的CRS的患病率高度相关。结论：这是首个欧洲首个CRS国际多中心患病率研究。在这项针对欧洲成年人的多中心调查中，大约十分之一的参与者患有明显的地域差异的CRS。在欧洲所有地区，吸烟都与CRS有关。
Background: Chronic rhinosinusitis (CRS) is a common health problem, with significant medical costs and impact on general health. Even so, prevalence figures for Europe are unavailable. In this study, conducted by the GA(2)LEN network of excellence, the European Position Paper on Rhinosinusitis and nasal Polyps ((EPOS)-O-3) diagnostic criteria are applied to estimate variation in the prevalence of Chronic rhinosinusitis (CRS) for Europe.Method: A postal questionnaire was sent to a random sample of adults aged 1575 years in 19 centres in Europe. Participants reported symptoms of CRS, and doctor diagnosed CRS, allergic rhinitis, age, gender and smoking history. Definition of CRS was based on the (EPOS)-O-3 diagnostic criteria: the presence of more than two of the symptoms: (i) nasal blockage, (ii) nasal discharge, (iii) facial pain/pressure or (iv) reduction in sense of smell, for >12 weeks in the past year - with at least one symptom being nasal blockage or discharge.Results: Information was obtained from 57 128 responders living in 19 centres in 12 countries. The overall prevalence of CRS by (EPOS)-O-3 criteria was 10.9% (range 6.9-27.1). CRS was more common in smokers than in nonsmokers (OR 1.7: 95% CI 1.6-1.9). The prevalence of self-reported physician-diagnosed CRS within centres was highly correlated with the prevalence of (EPOS)-O-3-diagnosed CRS.Conclusion: This is the first European international multicentre prevalence study of CRS. In this multicentre survey of adults in Europe, about one in ten participants had CRS with marked geographical variation. Smoking was associated with having CRS in all parts of Europe.